[Epidermodysplasia verruciformis: about a case]. 2018

Fatima-Zahra Agharbi
Hôpital Civil Tétouan, Tétouan, Maroc.

Epidermodysplasia verruciformis, also known as Lewandowsky-Lutz syndrome or tree man disease is a rare genetic skin disorder. It is characterized by abnormal susceptibility of the skin coating to human papillomaviruses (HPVs). It commonly affects people between the ages of 4 and 8, most often before the age of 20 years but it may exceptionally occur later. It is characterized by the appearance of scaly macules and sometimes exuberant pseudotumoral papules, mainly on hands and feet. HPV 5 and HPV-8 have been characterized in these lesions, viruses that are found in about 80% of the normal population. Other HPV types can sometimes be identified. Felix Lewandowskyand-Wilhelm Lutz provided the first clinical description of this disorder. The most frequently observed skin lesion is a macular rash similar to that of pityriasis versicolor associated with verrucous scaly papules. The risk of malignant transformation to squamous cell carcinoma is high. Several treatments have been tried (retinoids, interferon, cimetidine) with little or non-repeatable success. Sun protection, assiduous clinical monitoring and early excision of any lesion undergoing malignang transformation are essential. We report the case of a 30 year old man presenting with multiple verrucous lesions on limbs and trunk occurred at the age of 4 years associated with pityriasis versicolor-like lesions. Clinical examination didn't show suspicious lesions and retinoid therapy was started.

UI MeSH Term Description Entries
D008297 Male Males
D003879 Dermatologic Agents Drugs used to treat or prevent skin disorders or for the routine care of skin. Agent, Dermatologic,Agent, Dermatological,Agents, Dermatologic,Dermatologic Agent,Dermatological Agents,Agents, Dermatological,Dermatological Agent
D004819 Epidermodysplasia Verruciformis An autosomal recessive trait with impaired cell-mediated immunity. About 15 human papillomaviruses are implicated in associated infection, four of which lead to skin neoplasms. The disease begins in childhood with red papules and later spreads over the body as gray or yellow scales. Lewandowsky-Lutz Disease,Lutz-Lewandowsky Disease,Disease, Lewandowsky-Lutz,Disease, Lutz-Lewandowsky,Lewandowsky Lutz Disease,Lutz Lewandowsky Disease
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012176 Retinoids A group of tetraterpenes, with four terpene units joined head-to-tail. Biologically active members of this class are used clinically in the treatment of severe cystic ACNE; PSORIASIS; and other disorders of keratinization. Retinoid
D027383 Papillomaviridae A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.

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