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Wistar rats of a strain displaying spontaneous petit mal-like seizures and spike-wave EEG discharged (SWD) were injected i.p. with drugs affecting noradrenergic neurotransmission. The EEG and behavior were recorded. Drugs which decrease alpha-noradrenergic neurotransmission, prazosin (alpha 1-antagonist) and clonidine (alpha 2-agonist), increased SWD and were sedative in a dose-dependent manner. Drugs which increase alpha-noradrenergic neurotransmission, ST 587, cirazoline (alpha 1-agonists) and yohimbine (alpha 2-antagonist), reduced SWD and the latter two caused agitation. Drugs which interact with beta-noradrenergic transmission (salbutamol, isoprenaline and propranolol), monoamine oxidase inhibitors (nialamide and iproniazid), and a noradrenaline reuptake inhibitor (desipramine), did not affect SWD. These findings suggest that noradrenaline participates in the control of petit mal-like seizures in the rat, as in other types of seizures and other animal models.
G Micheletti, and
J M Warter, and
C Marescaux, and
A Depaulis, and
C Tranchant, and
L Rumbach, and
M Vergnes
January 1990,
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G Micheletti, and
J M Warter, and
C Marescaux, and
A Depaulis, and
C Tranchant, and
L Rumbach, and
M Vergnes
January 1991,
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G Micheletti, and
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A Depaulis, and
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M Vergnes
November 1953,
Maryland state medical journal,
G Micheletti, and
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C Marescaux, and
A Depaulis, and
C Tranchant, and
L Rumbach, and
M Vergnes
July 1969,
Postgraduate medicine,
G Micheletti, and
J M Warter, and
C Marescaux, and
A Depaulis, and
C Tranchant, and
L Rumbach, and
M Vergnes
January 1972,
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G Micheletti, and
J M Warter, and
C Marescaux, and
A Depaulis, and
C Tranchant, and
L Rumbach, and
M Vergnes
June 2006,
Anales de pediatria (Barcelona, Spain : 2003),
G Micheletti, and
J M Warter, and
C Marescaux, and
A Depaulis, and
C Tranchant, and
L Rumbach, and
M Vergnes
January 1972,
Neurologia i neurochirurgia polska,
G Micheletti, and
J M Warter, and
C Marescaux, and
A Depaulis, and
C Tranchant, and
L Rumbach, and
M Vergnes
January 1972,
Neurologia i neurochirurgia polska,
G Micheletti, and
J M Warter, and
C Marescaux, and
A Depaulis, and
C Tranchant, and
L Rumbach, and
M Vergnes
January 1988,
Neuroscience letters,
G Micheletti, and
J M Warter, and
C Marescaux, and
A Depaulis, and
C Tranchant, and
L Rumbach, and
M Vergnes
January 1992,
Journal of neural transmission. Supplementum,
