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The effect of adenohypophysial hormones on rat pineal melatonin content and release was examined in vitro. Medium concentration of radioimmunoassayable melatonin decreased after a 6 h exposure to 1-100 ng/ml FSH; pineal levels of melatonin were only decreased by 100 ng/ml FSH. LH (1-100 ng/ml) augmented significantly medium melatonin concentration, tissue levels being increased at 10 ng/ml LH. Parallel increases of explant and medium melatonin content were found after exposure to 1-100 ng/ml TSH. At the smallest concentration employed (1 ng/ml) prolactin increased melatonin content and release while at 100 ng/ml a significant depression of both parameters was found. Growth hormone (1-10 ng/ml) augmented melatonin levels in medium but failed to modify them at 100 ng/ml, although at this concentration tissue melatonin levels increased. ACTH did not modify pineal melatonin synthesis in vitro.
M I Vacas, and
M I Keller Sarmiento, and
E N Pereyra, and
G S Etchegoyen, and
D P Cardinali
January 1991,
Journal of pineal research,
M I Vacas, and
M I Keller Sarmiento, and
E N Pereyra, and
G S Etchegoyen, and
D P Cardinali
January 1989,
Psychoneuroendocrinology,
M I Vacas, and
M I Keller Sarmiento, and
E N Pereyra, and
G S Etchegoyen, and
D P Cardinali
June 1989,
Cellular and molecular neurobiology,
M I Vacas, and
M I Keller Sarmiento, and
E N Pereyra, and
G S Etchegoyen, and
D P Cardinali
January 1984,
Proceedings of the Western Pharmacology Society,
M I Vacas, and
M I Keller Sarmiento, and
E N Pereyra, and
G S Etchegoyen, and
D P Cardinali
January 1988,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
M I Vacas, and
M I Keller Sarmiento, and
E N Pereyra, and
G S Etchegoyen, and
D P Cardinali
August 1982,
Endocrinology,
M I Vacas, and
M I Keller Sarmiento, and
E N Pereyra, and
G S Etchegoyen, and
D P Cardinali
December 1991,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M I Vacas, and
M I Keller Sarmiento, and
E N Pereyra, and
G S Etchegoyen, and
D P Cardinali
February 1984,
European journal of pharmacology,
M I Vacas, and
M I Keller Sarmiento, and
E N Pereyra, and
G S Etchegoyen, and
D P Cardinali
January 1992,
Journal of pineal research,
M I Vacas, and
M I Keller Sarmiento, and
E N Pereyra, and
G S Etchegoyen, and
D P Cardinali
February 1987,
Neuroscience letters,
