Treatment of iron deficiency and iron deficiency anemia with intravenous ferric carboxymaltose in pregnancy. 2018

Ibrahim A Abdelazim, and Bassam Nusair, and Shikanova Svetlana, and Gulmira Zhurabekova
Department of Obstetrics and Gynecology, Ahmadi Hospital, Kuwait Oil Company (KOC), P.O. Box: 9758, 61008, Al Ahmadi, Kuwait. dr.ibrahimanwar@gmail.com.

Iron deficiency (ID) and iron deficiency anemia (IDA) in pregnancy are global health issues, affecting around 30% of women in high-resourced countries, and increasing to over 50% of women in low-resourced countries. Froessler et al. study published in Archives of Gynecology and Obstetrics (2018) 298: 75. https://doi.org/10.1007/s00404-018-4782-9 , raised many queries and we would like to know the answers of those queries from the authors if possible. Diagnosis of IDA should be based on hemoglobin concentration (gm/dl), serum ferritin (ug/l), mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH), and the efficacy of the treatment of IDA evaluated by comparing pre-treatment values of hemoglobin, serum ferritin, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) by the post-treatment values. Parenteral iron dose for correction of IDA calculated according to the formula; total iron needed in mg = 2.4 × pre-pregnancy weight in kg × (target hemoglobin concentration - actual hemoglobin concentration) gm/dl + 500 mg. The efficacy of the treatment of IDA evaluated by comparing pre-treatment values of hemoglobin, serum ferritin, MCV, and MCH by the post-treatment values. Parenteral iron dose for correction of IDA calculated according to the formula; total iron needed in mg = 2.4 + pre-pregnancy weight in kg + (target hemoglobin concentration - actual hemoglobin concentration) gm/dl + 500 mg.

UI MeSH Term Description Entries
D007501 Iron A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. Iron-56,Iron 56
D008320 Maltose A dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing. (Grant & Hackh's Chemical Dictionary, 5th ed)
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D005290 Ferric Compounds Inorganic or organic compounds containing trivalent iron. Compounds, Ferric
D006454 Hemoglobins The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements. Eryhem,Ferrous Hemoglobin,Hemoglobin,Hemoglobin, Ferrous
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D018798 Anemia, Iron-Deficiency Anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. The erythrocytes are hypochromic and microcytic and the iron binding capacity is increased. Iron-Deficiency Anemia,Anemias, Iron-Deficiency,Iron-Deficiency Anemias,Anemia, Iron Deficiency,Anemias, Iron Deficiency,Iron Deficiency Anemia,Iron Deficiency Anemias

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