-transparent.png){kind=logo}
A total of 452 cases of childhood malignant solid tumors were treated over the last twenty years at the National Children's Hospital. These included 175 cases of neuroblastoma, 64 cases of Wilms' tumor, 65 cases of malignant lymphoma, 45 cases of soft tissue sarcoma, 31 cases of hepatoma, 20 cases of malignant teratoma, 17 cases of testicular tumor, 7 cases of ovarian tumor and 28 cases of other forms of malignant solid tumor. Bone metastasis was observed in 62 of 175 cases of neuroblastoma, 3 of 64 cases of Wilms' tumor, one of 65 cases of malignant lymphoma, 4 of 45 cases of soft tissue sarcoma, one case of pulmonary blastoma and one case of osteogenic sarcoma, giving a total occurrence of bone metastasis in 72 of the 452 cases. The main sites of bone metastasis in neuroblastoma were the skull (61.4%), femur (56.8%), orbit (27.3%) and spine (22.7%). The average values of serum calcium and alkaline phosphatase activity showed no significant difference. The patients with bone metastasis were treated with a combination of radiation therapy and intensive chemotherapy, resulting in temporary improvement. The survival of patients with stage IV neuroblastoma with bone metastasis was worse than that of similar patients without bone metastasis.
N Taguchi, and
R Koide, and
Y Tsunematsu, and
T Kaneko, and
K Honda, and
Y Tsuchida, and
M Saeki, and
T Iwanaka, and
Y Kakizawa, and
K Shimizu
March 1986,
Current problems in surgery,
N Taguchi, and
R Koide, and
Y Tsunematsu, and
T Kaneko, and
K Honda, and
Y Tsuchida, and
M Saeki, and
T Iwanaka, and
Y Kakizawa, and
K Shimizu
December 1950,
Gan,
N Taguchi, and
R Koide, and
Y Tsunematsu, and
T Kaneko, and
K Honda, and
Y Tsuchida, and
M Saeki, and
T Iwanaka, and
Y Kakizawa, and
K Shimizu
March 1973,
Helvetica chirurgica acta,
N Taguchi, and
R Koide, and
Y Tsunematsu, and
T Kaneko, and
K Honda, and
Y Tsuchida, and
M Saeki, and
T Iwanaka, and
Y Kakizawa, and
K Shimizu
September 1970,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
N Taguchi, and
R Koide, and
Y Tsunematsu, and
T Kaneko, and
K Honda, and
Y Tsuchida, and
M Saeki, and
T Iwanaka, and
Y Kakizawa, and
K Shimizu
October 2003,
Indian journal of pathology & microbiology,
N Taguchi, and
R Koide, and
Y Tsunematsu, and
T Kaneko, and
K Honda, and
Y Tsuchida, and
M Saeki, and
T Iwanaka, and
Y Kakizawa, and
K Shimizu
January 1989,
Archives of pathology & laboratory medicine,
N Taguchi, and
R Koide, and
Y Tsunematsu, and
T Kaneko, and
K Honda, and
Y Tsuchida, and
M Saeki, and
T Iwanaka, and
Y Kakizawa, and
K Shimizu
August 1996,
Pediatric clinics of North America,
N Taguchi, and
R Koide, and
Y Tsunematsu, and
T Kaneko, and
K Honda, and
Y Tsuchida, and
M Saeki, and
T Iwanaka, and
Y Kakizawa, and
K Shimizu
April 1960,
The Journal of the Indiana State Medical Association,
N Taguchi, and
R Koide, and
Y Tsunematsu, and
T Kaneko, and
K Honda, and
Y Tsuchida, and
M Saeki, and
T Iwanaka, and
Y Kakizawa, and
K Shimizu
September 1954,
The Nebraska state medical journal,
N Taguchi, and
R Koide, and
Y Tsunematsu, and
T Kaneko, and
K Honda, and
Y Tsuchida, and
M Saeki, and
T Iwanaka, and
Y Kakizawa, and
K Shimizu
November 1968,
Minerva medica,
