Electroacupuncture Improves Baroreflex and γ-Aminobutyric Acid Type B Receptor-Mediated Responses in the Nucleus Tractus Solitarii of Hypertensive Rats. 2018

Qi Zhang, and Ying-Ying Tan, and Xiao-Hua Liu, and Fan-Rong Yao, and Dong-Yuan Cao
Shaanxi Key Laboratory of Chinese Medicine Encephalopathy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China.

Electroacupuncture (EA) has been reported to benefit hypertension, but the underlying mechanisms are still unclear. We hypothesized that EA attenuates hypertension, in part, through modulation of γ-aminobutyric acid (GABA) receptor function in the nucleus tractus solitarii (NTS). In the present study, the long-term effect of EA on GABA receptor function and expression was examined in the NTS of two-kidney, one-clip (2K1C) renovascular hypertensive rats. EA (0.1-0.4 mA, 2 and 15 Hz) was applied at Zusanli (ST36) acupoints overlying the deep fibular nerve for 30 min once a day for two weeks. The results showed that long-term EA treatment improved blood pressure (BP) and markedly restored the baroreflex response in 2K1C hypertensive rats. The increased pressor and depressor responses to microinjection of GABAB receptor agonist and antagonist into the NTS in the hypertensive rats were blunted by the EA treatment. Moreover, EA treatment attenuated the increased GABAB receptor expression in the NTS of hypertensive rats. In contrast, EA had no significant effect on the GABAA receptor function and expression in the NTS of 2K1C hypertensive rats. These findings suggest that the beneficial effects of EA on renovascular hypertension may be through modulation of functional GABAB receptors in the NTS.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297 Male Males
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015671 Electroacupuncture A form of acupuncture with electrical impulses passing through the needles to stimulate NERVE TISSUE. It can be used for ANALGESIA; ANESTHESIA; REHABILITATION; and treatment for diseases.
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D017552 Solitary Nucleus GRAY MATTER located in the dorsomedial part of the MEDULLA OBLONGATA associated with the solitary tract. The solitary nucleus receives inputs from most organ systems including the terminations of the facial, glossopharyngeal, and vagus nerves. It is a major coordinator of AUTONOMIC NERVOUS SYSTEM regulation of cardiovascular, respiratory, gustatory, gastrointestinal, and chemoreceptive aspects of HOMEOSTASIS. The solitary nucleus is also notable for the large number of NEUROTRANSMITTERS which are found therein. Nucleus Solitarius,Nuclei Tractus Solitarii,Nucleus Tractus Solitarii,Nucleus of Solitary Tract,Nucleus of Tractus Solitarius,Nucleus of the Solitary Tract,Solitary Nuclear Complex,Solitary Tract Nucleus,Complex, Solitary Nuclear,Complices, Solitary Nuclear,Nuclear Complex, Solitary,Nuclear Complices, Solitary,Nuclei Tractus Solitarius,Nucleus Tractus Solitarius,Nucleus, Solitary,Nucleus, Solitary Tract,Solitarii, Nuclei Tractus,Solitarius Nucleus, Tractus,Solitarius, Nuclei Tractus,Solitary Nuclear Complices,Tractus Solitarii, Nuclei,Tractus Solitarius Nucleus,Tractus Solitarius, Nuclei
D017704 Baroreflex A response by the BARORECEPTORS to increased BLOOD PRESSURE. Increased pressure stretches BLOOD VESSELS which activates the baroreceptors in the vessel walls. The net response of the CENTRAL NERVOUS SYSTEM is a reduction of central sympathetic outflow. This reduces blood pressure both by decreasing peripheral VASCULAR RESISTANCE and by lowering CARDIAC OUTPUT. Because the baroreceptors are tonically active, the baroreflex can compensate rapidly for both increases and decreases in blood pressure. Reflex, Baroreceptor,Baroreceptor Reflex,Baroreceptor Reflexes,Baroreflexes,Reflexes, Baroreceptor
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D018080 Receptors, GABA-B A subset of GABA RECEPTORS that signal through their interaction with HETEROTRIMERIC G-PROTEINS. Baclofen Receptors,GABA-B Receptors,Baclofen Receptor,GABA receptor rho1,GABA type B receptor, subunit 1,GABA(B)R1,GABA(B)R1 receptor,GABA(B)R1a protein,GABA(B)R1a receptor,GABA(B)R1b protein,GABA(B)R1b receptor,GABA-B Receptor,GABBR1 protein,GB1a protein,GB1b protein,GBR1B protein,Receptors, Baclofen,rho1 subunit, GABA receptor

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