The number of partially and completely edentulous patients requiring removable prosthetic treatment has increased constantly and denture wearers often have an associated oral status pathology. The purpose of this article is to present removable prosthetic treatment options that we chose for the extended partially edentulous and completely edentulous patients who required prosthetic rehabilitation treatment. We conducted this study on 52 extended partially edentulous and completely edentulous patients. We recorded in the examination chart the characteristics of the mucosal membrane covering the denture supporting structure and the peripheral structures and we performed a statistical analysis using Microsoft Excel. The prosthetic treatment phases were individualized according to morphological characteristics of the oral mucosal substrate.