Biomaterial Database

Age-related differences in event-related potentials and pupillary responses in cued reaction time tasks. 2019

Maria J Ribeiro, and Miguel Castelo-Branco

CIBIT, Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Coimbra, Portugal; CNC.IBILI, University of Coimbra, Coimbra, Portugal; Visual Neuroscience Laboratory, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal. Electronic address: mjribeiro@fmed.uc.pt.

Deficits in the noradrenergic system are associated with age-related cognitive decline, yet how healthy aging influences the functional properties of this arousal system is still poorly understood. We addressed this question in humans using pupillometry, a well-established indicator of activity levels in the locus coeruleus (LC), the main noradrenergic center in the brain. We recorded the pupillogram and the electroencephalogram of 36 young and 39 older adults, while they were engaged in cued reaction time tasks known to elicit LC responses in monkeys. Event-related potentials (ERPs) revealed significant group differences. Older adults showed higher cortical activation during preparatory processes reflected in enhanced cue-evoked frontocentral ERPs and reduced parietal ERPs at the time of the motor response. In contrast, the amplitude of the task-related pupillary responses did not show a significant group effect. Our findings suggest that aging-related changes in cortical processing during motor preparation and execution, as documented by electroencephalogram, are not accompanied by changes in the amplitude of activation of the LC, as documented by pupillography.

UI	MeSH Term	Description	Entries
D008125	Locus Coeruleus	Bluish-colored region in the superior angle of the FOURTH VENTRICLE floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the PERIAQUEDUCTAL GRAY.	Locus Caeruleus Complex,Locus Caeruleus,Locus Ceruleus,Locus Ceruleus Complex,Locus Coeruleus Complex,Nucleus Pigmentosus Pontis,Caeruleus Complex, Locus,Complex, Locus Caeruleus,Complex, Locus Ceruleus,Complex, Locus Coeruleus,Pontis, Nucleus Pigmentosus
D011597	Psychomotor Performance	The coordination of a sensory or ideational (cognitive) process and a motor activity.	Perceptual Motor Performance,Sensory Motor Performance,Visual Motor Coordination,Coordination, Visual Motor,Coordinations, Visual Motor,Motor Coordination, Visual,Motor Coordinations, Visual,Motor Performance, Perceptual,Motor Performance, Sensory,Motor Performances, Perceptual,Motor Performances, Sensory,Perceptual Motor Performances,Performance, Perceptual Motor,Performance, Psychomotor,Performance, Sensory Motor,Performances, Perceptual Motor,Performances, Psychomotor,Performances, Sensory Motor,Psychomotor Performances,Sensory Motor Performances,Visual Motor Coordinations
D011680	Pupil	The aperture in the iris through which light passes.	Pupils
D011930	Reaction Time	The time from the onset of a stimulus until a response is observed.	Response Latency,Response Speed,Response Time,Latency, Response,Reaction Times,Response Latencies,Response Times,Speed, Response,Speeds, Response
D003463	Cues	Signals for an action; that specific portion of a perceptual field or pattern of stimuli to which a subject has learned to respond.	Cue
D004569	Electroencephalography	Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.	EEG,Electroencephalogram,Electroencephalograms
D005071	Evoked Potentials	Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported.	Event Related Potential,Event-Related Potentials,Evoked Potential,N100 Evoked Potential,P50 Evoked Potential,N1 Wave,N100 Evoked Potentials,N2 Wave,N200 Evoked Potentials,N3 Wave,N300 Evoked Potentials,N4 Wave,N400 Evoked Potentials,P2 Wave,P200 Evoked Potentials,P50 Evoked Potentials,P50 Wave,P600 Evoked Potentials,Potentials, Event-Related,Event Related Potentials,Event-Related Potential,Evoked Potential, N100,Evoked Potential, N200,Evoked Potential, N300,Evoked Potential, N400,Evoked Potential, P200,Evoked Potential, P50,Evoked Potential, P600,Evoked Potentials, N100,Evoked Potentials, N200,Evoked Potentials, N300,Evoked Potentials, N400,Evoked Potentials, P200,Evoked Potentials, P50,Evoked Potentials, P600,N1 Waves,N2 Waves,N200 Evoked Potential,N3 Waves,N300 Evoked Potential,N4 Waves,N400 Evoked Potential,P2 Waves,P200 Evoked Potential,P50 Waves,P600 Evoked Potential,Potential, Event Related,Potential, Event-Related,Potential, Evoked,Potentials, Event Related,Potentials, Evoked,Potentials, N400 Evoked,Related Potential, Event,Related Potentials, Event,Wave, N1,Wave, N2,Wave, N3,Wave, N4,Wave, P2,Wave, P50,Waves, N1,Waves, N2,Waves, N3,Waves, N4,Waves, P2,Waves, P50
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000073656	Healthy Aging	The development and maintenance of optimal physical, mental, spiritual, and social well-being and function with advancing age.	Ageing Well,Aging Well,Healthy Ageing,Well Aging,Ageing, Healthy,Aging, Healthy,Aging, Well,Well, Ageing,Well, Aging
D000161	Acoustic Stimulation	Use of sound to elicit a response in the nervous system.	Auditory Stimulation,Stimulation, Acoustic,Stimulation, Auditory