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The absorption of a vasoconstrictive substance labeled with 14C, after application as eye-drops, was studied in animal experiments. After iatrogenous obstruction of the lacrimal punctum with tissue adhesive, a maximum of 6% of the substance could be measured in the total blood volume after an exposure time of 60 min. High relative concentration of the drug could be found in cornea, conjunctiva, and iris, while the concentration in lens, vitreous body, and the rest of the eye was low. The results represent the maximum values of resorption. Additional studies, made by 99mTc-pertechnetate microscintigraphy of the lacrimal drainage apparatus of the rabbit were also performed. The transport of an eye-drop from cornea and conjunctiva to the nasal cavum was found to be very rapid. Therefore it seems to be of little value to carry out investigations on the absorption of eye-drops over long time periods without prior occlusion of the lacrimal punctum.
H von Denffer, and
J Dressler, and
W Schmahl
November 1975,
Laryngologie, Rhinologie, Otologie,
H von Denffer, and
J Dressler, and
W Schmahl
March 1981,
Klinika oczna,
H von Denffer, and
J Dressler, and
W Schmahl
January 1980,
Neuro-Chirurgie,
H von Denffer, and
J Dressler, and
W Schmahl
January 1980,
International archives of occupational and environmental health,
H von Denffer, and
J Dressler, and
W Schmahl
July 1977,
MMW, Munchener medizinische Wochenschrift,
H von Denffer, and
J Dressler, and
W Schmahl
July 2004,
International journal of pediatric otorhinolaryngology,
H von Denffer, and
J Dressler, and
W Schmahl
December 1977,
Geburtshilfe und Frauenheilkunde,
H von Denffer, and
J Dressler, and
W Schmahl
November 1978,
Chirurgie; memoires de l'Academie de chirurgie,
H von Denffer, and
J Dressler, and
W Schmahl
December 1979,
Der Nervenarzt,
H von Denffer, and
J Dressler, and
W Schmahl
March 1973,
Majallat tibb al-asnan al-Suriyah,
