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The cyclic chemotherapy scheme OS I/75 was tried in 6 patients with newly diagnosed osteosarcoma and in 3 patients with secondary metastases. The treatment consists of high dose methotrexate, followed by citrovorum-factor rescue, doxorubicine (Adriblastin) and cyclophosphamide (Endoxan). All 6 primary patients are in a continuous remission of 6+ to 21+ months (median 12+ months). The length of remission in the patients with metastases is 5.5+ and 8+ months. The haematological side effects led to an average prolongation of the cycle by 11 days in a planned cycle duration of 42 days. However, they were readily manageable. Among the other side effects two cases of Adriblastin myocardiopathy are remarkable which became apparent after methotrexate and ifosfamide. In order to improve possibilities for treatment regional centralisation of patient care and interdisciplinary and supraregional cooperation of treatment centres are necessary. A prospective treatment programme has been developed for the Federal Republic of Germany and Austria.
K Winkler, and
G Gaedicke, and
I Grosch-Wörner, and
G Marsmann, and
G Delling, and
G Landbeck
May 1976,
Archiv fur orthopadische und Unfall-Chirurgie,
K Winkler, and
G Gaedicke, and
I Grosch-Wörner, and
G Marsmann, and
G Delling, and
G Landbeck
March 1981,
Wiener klinische Wochenschrift,
K Winkler, and
G Gaedicke, and
I Grosch-Wörner, and
G Marsmann, and
G Delling, and
G Landbeck
February 1977,
Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca,
K Winkler, and
G Gaedicke, and
I Grosch-Wörner, and
G Marsmann, and
G Delling, and
G Landbeck
January 1978,
Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie,
K Winkler, and
G Gaedicke, and
I Grosch-Wörner, and
G Marsmann, and
G Delling, and
G Landbeck
January 1977,
Revista catarinense de odontologia,
K Winkler, and
G Gaedicke, and
I Grosch-Wörner, and
G Marsmann, and
G Delling, and
G Landbeck
June 1974,
Therapeutische Umschau. Revue therapeutique,
K Winkler, and
G Gaedicke, and
I Grosch-Wörner, and
G Marsmann, and
G Delling, and
G Landbeck
January 1979,
Medecine tropicale : revue du Corps de sante colonial,
K Winkler, and
G Gaedicke, and
I Grosch-Wörner, and
G Marsmann, and
G Delling, and
G Landbeck
October 1978,
Revista medica de Chile,
K Winkler, and
G Gaedicke, and
I Grosch-Wörner, and
G Marsmann, and
G Delling, and
G Landbeck
January 1982,
Zentralblatt fur Chirurgie,
K Winkler, and
G Gaedicke, and
I Grosch-Wörner, and
G Marsmann, and
G Delling, and
G Landbeck
March 1982,
Deutsche medizinische Wochenschrift (1946),
