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Sera from 55 patients with positivity for anti-HTLV III antibodies, including 24 "healthy" subjects, 29 LAS and 2 AIDS, were examined by means of high resolution agarose gel electrophoresis and immunofixation, in order to evaluate the occurrence of monoclonal-oligoclonal immunoglobulin patterns. Monoclonal-oligoclonal immunoglobulins were found in 20.8% of "healthy" subjects and in 72.4% of LAS patients. Furthermore, a lower but significant prevalence of monoclonal-oligoclonal immunoglobulins was found in a control group including patients with high-titre positivity for anti-CMV and anti-EBV antibodies. Considering the consistent association between EBV-CMV and HTLV III infection, it is concluded that at least a part of monoclonal-oligoclonal immunoglobulins found in LAS-AIDS patients are likely to be induced by these associated viral infections. On the other hand, the finding of monoclonal-oligoclonal immunoglobulins in "healthy" HTLV III-positive subjects points out a possible direct stimulatory effect of HTLV III on B-cell lineage.
P G Sala, and
S Mazzolini, and
E Tonutti, and
C Crucil, and
E Pitzus, and
M Bramezza
January 1989,
Nouvelle revue francaise d'hematologie,
P G Sala, and
S Mazzolini, and
E Tonutti, and
C Crucil, and
E Pitzus, and
M Bramezza
January 1985,
Microbiology and immunology,
P G Sala, and
S Mazzolini, and
E Tonutti, and
C Crucil, and
E Pitzus, and
M Bramezza
December 1985,
Annals of internal medicine,
P G Sala, and
S Mazzolini, and
E Tonutti, and
C Crucil, and
E Pitzus, and
M Bramezza
August 1987,
Clinical biochemistry,
P G Sala, and
S Mazzolini, and
E Tonutti, and
C Crucil, and
E Pitzus, and
M Bramezza
August 1987,
Archives of surgery (Chicago, Ill. : 1960),
P G Sala, and
S Mazzolini, and
E Tonutti, and
C Crucil, and
E Pitzus, and
M Bramezza
August 1989,
Clinical chemistry,
P G Sala, and
S Mazzolini, and
E Tonutti, and
C Crucil, and
E Pitzus, and
M Bramezza
January 1986,
AIDS research,
P G Sala, and
S Mazzolini, and
E Tonutti, and
C Crucil, and
E Pitzus, and
M Bramezza
December 1988,
Annals of neurology,
P G Sala, and
S Mazzolini, and
E Tonutti, and
C Crucil, and
E Pitzus, and
M Bramezza
January 1988,
Acta haematologica,
P G Sala, and
S Mazzolini, and
E Tonutti, and
C Crucil, and
E Pitzus, and
M Bramezza
April 1979,
British medical journal,
