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The effect of chronic administration of haloperidol on alpha 1-, alpha 2-, and beta-adrenoceptors, cholinergic muscarinic, GABAA and benzodiazepine receptors in the cerebral cortex of the rat was investigated. Doses of 0.3 and 2 mg/kg of haloperidol during 7 days increased markedly the density of alpha 1-adrenoceptors without changes in affinity. The alpha 2- and beta-adrenoceptors were not modified after neuroleptic administration. The number of muscarinic receptors were also increased after haloperidol treatment (2 mg/kg/day). However, the GABAA and benzodiazepine binding sites remained unchanged. In the brainstem an increment in the alpha 1-, but not the beta-adrenoceptors was observed. The well known increase in the dopamine receptors in the striatum was confirmed. These observations demonstrate a multireceptor effect of haloperidol in the cerebral cortex.
J H Pazo, and
M Levi de Stein, and
D Jerusalinsky, and
M L Novas, and
S Raskovsky, and
O R Tumilasci, and
J H Medina, and
E De Robertis
January 1989,
General pharmacology,
J H Pazo, and
M Levi de Stein, and
D Jerusalinsky, and
M L Novas, and
S Raskovsky, and
O R Tumilasci, and
J H Medina, and
E De Robertis
October 1986,
European journal of pharmacology,
J H Pazo, and
M Levi de Stein, and
D Jerusalinsky, and
M L Novas, and
S Raskovsky, and
O R Tumilasci, and
J H Medina, and
E De Robertis
December 1983,
Journal of neurochemistry,
J H Pazo, and
M Levi de Stein, and
D Jerusalinsky, and
M L Novas, and
S Raskovsky, and
O R Tumilasci, and
J H Medina, and
E De Robertis
July 1983,
Neuropharmacology,
J H Pazo, and
M Levi de Stein, and
D Jerusalinsky, and
M L Novas, and
S Raskovsky, and
O R Tumilasci, and
J H Medina, and
E De Robertis
February 1981,
Naunyn-Schmiedeberg's archives of pharmacology,
J H Pazo, and
M Levi de Stein, and
D Jerusalinsky, and
M L Novas, and
S Raskovsky, and
O R Tumilasci, and
J H Medina, and
E De Robertis
August 1989,
The Journal of urology,
J H Pazo, and
M Levi de Stein, and
D Jerusalinsky, and
M L Novas, and
S Raskovsky, and
O R Tumilasci, and
J H Medina, and
E De Robertis
January 1988,
Journal of neural transmission,
J H Pazo, and
M Levi de Stein, and
D Jerusalinsky, and
M L Novas, and
S Raskovsky, and
O R Tumilasci, and
J H Medina, and
E De Robertis
December 1984,
Neuroscience,
J H Pazo, and
M Levi de Stein, and
D Jerusalinsky, and
M L Novas, and
S Raskovsky, and
O R Tumilasci, and
J H Medina, and
E De Robertis
February 1981,
Journal of pharmacobio-dynamics,
J H Pazo, and
M Levi de Stein, and
D Jerusalinsky, and
M L Novas, and
S Raskovsky, and
O R Tumilasci, and
J H Medina, and
E De Robertis
April 1988,
Brain research,
