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We investigated whether stimulation of baboon erythrocyte beta-adrenoreceptors affects oxygen transport by haemoglobin. To assess oxygen transport we measured the PO2 at which the haemoglobin was 50% saturated (P50) and the Hill parameter 'n'. Blood at PO2s ranging from 10 to 90 mm Hg was exposed to a 10(-3) M concentration of the agonists l-isoproterenol, l-epinephrine and l-norepinephrine in the presence and absence of 10(-5) M dl-propranolol. None of the adrenergic agents which were used in these experiments produced significant changes in either 'n' or P50 and the concentrations of 2,3-diphosphoglycerate and lactate were not altered by the agonists. We conclude from these results that short-term adrenergic stimulation of the baboon erythrocyte beta-adrenoreceptor does not affect factors known to influence oxygen transport, oxygen delivery or haemoglobin itself.
E E Susanni, and
T Mundel, and
G Mitchell, and
C Rosendorff
January 1983,
Kardiologia polska,
E E Susanni, and
T Mundel, and
G Mitchell, and
C Rosendorff
January 1977,
Methods in enzymology,
E E Susanni, and
T Mundel, and
G Mitchell, and
C Rosendorff
August 1986,
Biochemical pharmacology,
E E Susanni, and
T Mundel, and
G Mitchell, and
C Rosendorff
January 1975,
Advances in cyclic nucleotide research,
E E Susanni, and
T Mundel, and
G Mitchell, and
C Rosendorff
November 1981,
The New England journal of medicine,
E E Susanni, and
T Mundel, and
G Mitchell, and
C Rosendorff
February 1978,
Journal of cyclic nucleotide research,
E E Susanni, and
T Mundel, and
G Mitchell, and
C Rosendorff
January 1971,
The Journal of clinical pharmacology and new drugs,
E E Susanni, and
T Mundel, and
G Mitchell, and
C Rosendorff
January 1990,
Methods in enzymology,
E E Susanni, and
T Mundel, and
G Mitchell, and
C Rosendorff
October 1997,
Nihon rinsho. Japanese journal of clinical medicine,
E E Susanni, and
T Mundel, and
G Mitchell, and
C Rosendorff
November 2002,
Herz,
