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We investigated possible association of and linkage between HLA and familial polyposis coli (FPC). In 182 individuals from 66 pedigrees of FPC and 108 individuals from a normal population, HLA-A, -B, and -C antigens were determined. When the frequencies of HLA antigens in 66 unrelated patients and in normal controls were compared, no association of FPC with HLA was observed. For the linkage analysis, HLA haplotypes of 17 affected sib pairs were investigated by the affected sib pair method. The number of pairs which shared two, one, and no haplotypes identical by descent was not significantly different from the number expected with random occurrence (P greater than 0.95). Finally, seven families were analyzed using Morton's sequential test. A maximum lod score of -0.056 at a recombination fraction of 0.4, and a lod of -3.089 at a recombination fraction of 0.05 were obtained. Therefore, there is neither an association of nor linkage between FPC and HLA.
M Sasaki, and
K Sugio, and
J Soejima, and
T Ikeuchi, and
A Tonomura, and
T Iwama, and
J Utsunomiya, and
T Sasazuki
November 1983,
Tissue antigens,
M Sasaki, and
K Sugio, and
J Soejima, and
T Ikeuchi, and
A Tonomura, and
T Iwama, and
J Utsunomiya, and
T Sasazuki
April 1988,
The American journal of gastroenterology,
M Sasaki, and
K Sugio, and
J Soejima, and
T Ikeuchi, and
A Tonomura, and
T Iwama, and
J Utsunomiya, and
T Sasazuki
September 1987,
The American journal of gastroenterology,
M Sasaki, and
K Sugio, and
J Soejima, and
T Ikeuchi, and
A Tonomura, and
T Iwama, and
J Utsunomiya, and
T Sasazuki
August 1976,
Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen,
M Sasaki, and
K Sugio, and
J Soejima, and
T Ikeuchi, and
A Tonomura, and
T Iwama, and
J Utsunomiya, and
T Sasazuki
December 1983,
Archives of disease in childhood,
M Sasaki, and
K Sugio, and
J Soejima, and
T Ikeuchi, and
A Tonomura, and
T Iwama, and
J Utsunomiya, and
T Sasazuki
October 1987,
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
M Sasaki, and
K Sugio, and
J Soejima, and
T Ikeuchi, and
A Tonomura, and
T Iwama, and
J Utsunomiya, and
T Sasazuki
March 1987,
Danish medical bulletin,
M Sasaki, and
K Sugio, and
J Soejima, and
T Ikeuchi, and
A Tonomura, and
T Iwama, and
J Utsunomiya, and
T Sasazuki
January 1987,
Seminars in surgical oncology,
M Sasaki, and
K Sugio, and
J Soejima, and
T Ikeuchi, and
A Tonomura, and
T Iwama, and
J Utsunomiya, and
T Sasazuki
July 1978,
Maryland state medical journal,
M Sasaki, and
K Sugio, and
J Soejima, and
T Ikeuchi, and
A Tonomura, and
T Iwama, and
J Utsunomiya, and
T Sasazuki
January 1980,
Progress in medical genetics,
