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Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa. 2019
Jonathan D Edgeworth, and
Domenico Merante, and
Sanjay Patel, and
Christopher Young, and
Paul Jones, and
Seema Vithlani, and
Duncan Wyncoll, and
Peter Roberts, and
Andrew Jones, and
Tsutae Den Nagata, and
Mari Ariyasu, and
David M Livermore, and
Richard Beale
Department of Infectious Diseases, Guy's Hospital, Kings College London, London, United Kingdom.
Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated native aortic valve endocarditis due to an extended-spectrum beta-lactamase-positive Pseudomonas aeruginosa susceptible in vitro only to colistin, following failure of conventional therapeutic options.
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