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Human Leukocyte Antigen Associations in Drug Hypersensitivity Reactions. 2018
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, University of Florida, PO Box 103633, Gainesville, FL 32610-3633, USA.
Severe adverse drug reactions are a common cause of morbidity and mortality. Some of the most severe reactions are immunologically mediated and have been linked to specific HLA alleles. The mechanisms underlying HLA-associated drug hypersensitivity are complex and not fully understood. Recent findings have provided insight into recognition mechanisms underlying drug-induced immunopathogenesis and criteria for increasing positive prediction of hypersensitivity. Refining pharmocogenetic testing strategies to better identify at-risk individuals can improve hypersensitivity prevention and mechanism characterization.
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