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The circadian clock is a molecular pacemaker that produces 24-hr physiological cycles known as circadian rhythms. How the clock regulates stem cells is an emerging area of research with many outstanding questions. We tested clock function in vivo at the single cell resolution in the Drosophila intestine, a tissue that is exquisitely sensitive to environmental cues and has circadian rhythms in regeneration. Our results indicate that circadian clocks function in intestinal stem cells and enterocytes but are downregulated during enteroendocrine cell differentiation. Drosophila intestinal cells are principally synchronized by the photoperiod, but intestinal stem cell clocks are highly responsive to signaling pathways that comprise their niche, and we find that the Wnt and Hippo signaling pathways positively regulate stem cell circadian clock function. These data reveal that intestinal stem cell circadian rhythms are regulated by cellular signaling and provide insight as to how clocks may be altered during physiological changes such as regeneration and aging.
Kathyani Parasram, and
Nathaniel Bernardon, and
Maha Hammoud, and
Hanna Chang, and
Li He, and
Norbert Perrimon, and
Phillip Karpowicz
April 2020,
Cellular and molecular life sciences : CMLS,
Kathyani Parasram, and
Nathaniel Bernardon, and
Maha Hammoud, and
Hanna Chang, and
Li He, and
Norbert Perrimon, and
Phillip Karpowicz
November 2017,
Developmental biology,
Kathyani Parasram, and
Nathaniel Bernardon, and
Maha Hammoud, and
Hanna Chang, and
Li He, and
Norbert Perrimon, and
Phillip Karpowicz
April 2013,
Cell reports,
Kathyani Parasram, and
Nathaniel Bernardon, and
Maha Hammoud, and
Hanna Chang, and
Li He, and
Norbert Perrimon, and
Phillip Karpowicz
January 2015,
Methods in enzymology,
Kathyani Parasram, and
Nathaniel Bernardon, and
Maha Hammoud, and
Hanna Chang, and
Li He, and
Norbert Perrimon, and
Phillip Karpowicz
December 2022,
The EMBO journal,
Kathyani Parasram, and
Nathaniel Bernardon, and
Maha Hammoud, and
Hanna Chang, and
Li He, and
Norbert Perrimon, and
Phillip Karpowicz
January 2016,
Molecular vision,
Kathyani Parasram, and
Nathaniel Bernardon, and
Maha Hammoud, and
Hanna Chang, and
Li He, and
Norbert Perrimon, and
Phillip Karpowicz
November 2005,
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
Kathyani Parasram, and
Nathaniel Bernardon, and
Maha Hammoud, and
Hanna Chang, and
Li He, and
Norbert Perrimon, and
Phillip Karpowicz
November 2019,
Cancer discovery,
Kathyani Parasram, and
Nathaniel Bernardon, and
Maha Hammoud, and
Hanna Chang, and
Li He, and
Norbert Perrimon, and
Phillip Karpowicz
April 2016,
Cell,
Kathyani Parasram, and
Nathaniel Bernardon, and
Maha Hammoud, and
Hanna Chang, and
Li He, and
Norbert Perrimon, and
Phillip Karpowicz
February 2016,
Alcoholism, clinical and experimental research,
