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Improved reference genome of Aedes aegypti informs arbovirus vector control. 2018
Benjamin J Matthews, and
Olga Dudchenko, and
Sarah B Kingan, and
Sergey Koren, and
Igor Antoshechkin, and
Jacob E Crawford, and
William J Glassford, and
Margaret Herre, and
Seth N Redmond, and
Noah H Rose, and
Gareth D Weedall, and
Yang Wu, and
Sanjit S Batra, and
Carlos A Brito-Sierra, and
Steven D Buckingham, and
Corey L Campbell, and
Saki Chan, and
Eric Cox, and
Benjamin R Evans, and
Thanyalak Fansiri, and
Igor Filipović, and
Albin Fontaine, and
Andrea Gloria-Soria, and
Richard Hall, and
Vinita S Joardar, and
Andrew K Jones, and
Raissa G G Kay, and
Vamsi K Kodali, and
Joyce Lee, and
Gareth J Lycett, and
Sara N Mitchell, and
Jill Muehling, and
Michael R Murphy, and
Arina D Omer, and
Frederick A Partridge, and
Paul Peluso, and
Aviva Presser Aiden, and
Vidya Ramasamy, and
Gordana Rašić, and
Sourav Roy, and
Karla Saavedra-Rodriguez, and
Shruti Sharan, and
Atashi Sharma, and
Melissa Laird Smith, and
Joe Turner, and
Allison M Weakley, and
Zhilei Zhao, and
Omar S Akbari, and
William C Black, and
Han Cao, and
Alistair C Darby, and
Catherine A Hill, and
J Spencer Johnston, and
Terence D Murphy, and
Alexander S Raikhel, and
David B Sattelle, and
Igor V Sharakhov, and
Bradley J White, and
Li Zhao, and
Erez Lieberman Aiden, and
Richard S Mann, and
Louis Lambrechts, and
Jeffrey R Powell, and
Maria V Sharakhova, and
Zhijian Tu, and
Hugh M Robertson, and
Carolyn S McBride, and
Alex R Hastie, and
Jonas Korlach, and
Daniel E Neafsey, and
Adam M Phillippy, and
Leslie B Vosshall
Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY, USA. bnmtthws@gmail.com.
Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector.
Related Publications
Benjamin J Matthews, and
Olga Dudchenko, and
Sarah B Kingan, and
Sergey Koren, and
Igor Antoshechkin, and
Jacob E Crawford, and
William J Glassford, and
Margaret Herre, and
Seth N Redmond, and
Noah H Rose, and
Gareth D Weedall, and
Yang Wu, and
Sanjit S Batra, and
Carlos A Brito-Sierra, and
Steven D Buckingham, and
Corey L Campbell, and
Saki Chan, and
Eric Cox, and
Benjamin R Evans, and
Thanyalak Fansiri, and
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Albin Fontaine, and
Andrea Gloria-Soria, and
Richard Hall, and
Vinita S Joardar, and
Andrew K Jones, and
Raissa G G Kay, and
Vamsi K Kodali, and
Joyce Lee, and
Gareth J Lycett, and
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Jill Muehling, and
Michael R Murphy, and
Arina D Omer, and
Frederick A Partridge, and
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Aviva Presser Aiden, and
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Melissa Laird Smith, and
Joe Turner, and
Allison M Weakley, and
Zhilei Zhao, and
Omar S Akbari, and
William C Black, and
Han Cao, and
Alistair C Darby, and
Catherine A Hill, and
J Spencer Johnston, and
Terence D Murphy, and
Alexander S Raikhel, and
David B Sattelle, and
Igor V Sharakhov, and
Bradley J White, and
Li Zhao, and
Erez Lieberman Aiden, and
Richard S Mann, and
Louis Lambrechts, and
Jeffrey R Powell, and
Maria V Sharakhova, and
Zhijian Tu, and
Hugh M Robertson, and
Carolyn S McBride, and
Alex R Hastie, and
Jonas Korlach, and
Daniel E Neafsey, and
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Leslie B Vosshall
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Olga Dudchenko, and
Sarah B Kingan, and
Sergey Koren, and
Igor Antoshechkin, and
Jacob E Crawford, and
William J Glassford, and
Margaret Herre, and
Seth N Redmond, and
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Gareth D Weedall, and
Yang Wu, and
Sanjit S Batra, and
Carlos A Brito-Sierra, and
Steven D Buckingham, and
Corey L Campbell, and
Saki Chan, and
Eric Cox, and
Benjamin R Evans, and
Thanyalak Fansiri, and
Igor Filipović, and
Albin Fontaine, and
Andrea Gloria-Soria, and
Richard Hall, and
Vinita S Joardar, and
Andrew K Jones, and
Raissa G G Kay, and
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Sourav Roy, and
Karla Saavedra-Rodriguez, and
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William C Black, and
Han Cao, and
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J Spencer Johnston, and
Terence D Murphy, and
Alexander S Raikhel, and
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Li Zhao, and
Erez Lieberman Aiden, and
Richard S Mann, and
Louis Lambrechts, and
Jeffrey R Powell, and
Maria V Sharakhova, and
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Hugh M Robertson, and
Carolyn S McBride, and
Alex R Hastie, and
Jonas Korlach, and
Daniel E Neafsey, and
Adam M Phillippy, and
Leslie B Vosshall
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William J Glassford, and
Margaret Herre, and
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Raissa G G Kay, and
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Joyce Lee, and
Gareth J Lycett, and
Sara N Mitchell, and
Jill Muehling, and
Michael R Murphy, and
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Frederick A Partridge, and
Paul Peluso, and
Aviva Presser Aiden, and
Vidya Ramasamy, and
Gordana Rašić, and
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Alex R Hastie, and
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Daniel E Neafsey, and
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Corey L Campbell, and
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Andrew K Jones, and
Raissa G G Kay, and
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Igor Antoshechkin, and
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Vinita S Joardar, and
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Vamsi K Kodali, and
Joyce Lee, and
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Jill Muehling, and
Michael R Murphy, and
Arina D Omer, and
Frederick A Partridge, and
Paul Peluso, and
Aviva Presser Aiden, and
Vidya Ramasamy, and
Gordana Rašić, and
Sourav Roy, and
Karla Saavedra-Rodriguez, and
Shruti Sharan, and
Atashi Sharma, and
Melissa Laird Smith, and
Joe Turner, and
Allison M Weakley, and
Zhilei Zhao, and
Omar S Akbari, and
William C Black, and
Han Cao, and
Alistair C Darby, and
Catherine A Hill, and
J Spencer Johnston, and
Terence D Murphy, and
Alexander S Raikhel, and
David B Sattelle, and
Igor V Sharakhov, and
Bradley J White, and
Li Zhao, and
Erez Lieberman Aiden, and
Richard S Mann, and
Louis Lambrechts, and
Jeffrey R Powell, and
Maria V Sharakhova, and
Zhijian Tu, and
Hugh M Robertson, and
Carolyn S McBride, and
Alex R Hastie, and
Jonas Korlach, and
Daniel E Neafsey, and
Adam M Phillippy, and
Leslie B Vosshall
July 2021,
Genome biology,
Benjamin J Matthews, and
Olga Dudchenko, and
Sarah B Kingan, and
Sergey Koren, and
Igor Antoshechkin, and
Jacob E Crawford, and
William J Glassford, and
Margaret Herre, and
Seth N Redmond, and
Noah H Rose, and
Gareth D Weedall, and
Yang Wu, and
Sanjit S Batra, and
Carlos A Brito-Sierra, and
Steven D Buckingham, and
Corey L Campbell, and
Saki Chan, and
Eric Cox, and
Benjamin R Evans, and
Thanyalak Fansiri, and
Igor Filipović, and
Albin Fontaine, and
Andrea Gloria-Soria, and
Richard Hall, and
Vinita S Joardar, and
Andrew K Jones, and
Raissa G G Kay, and
Vamsi K Kodali, and
Joyce Lee, and
Gareth J Lycett, and
Sara N Mitchell, and
Jill Muehling, and
Michael R Murphy, and
Arina D Omer, and
Frederick A Partridge, and
Paul Peluso, and
Aviva Presser Aiden, and
Vidya Ramasamy, and
Gordana Rašić, and
Sourav Roy, and
Karla Saavedra-Rodriguez, and
Shruti Sharan, and
Atashi Sharma, and
Melissa Laird Smith, and
Joe Turner, and
Allison M Weakley, and
Zhilei Zhao, and
Omar S Akbari, and
William C Black, and
Han Cao, and
Alistair C Darby, and
Catherine A Hill, and
J Spencer Johnston, and
Terence D Murphy, and
Alexander S Raikhel, and
David B Sattelle, and
Igor V Sharakhov, and
Bradley J White, and
Li Zhao, and
Erez Lieberman Aiden, and
Richard S Mann, and
Louis Lambrechts, and
Jeffrey R Powell, and
Maria V Sharakhova, and
Zhijian Tu, and
Hugh M Robertson, and
Carolyn S McBride, and
Alex R Hastie, and
Jonas Korlach, and
Daniel E Neafsey, and
Adam M Phillippy, and
Leslie B Vosshall
February 2023,
Viruses,
Benjamin J Matthews, and
Olga Dudchenko, and
Sarah B Kingan, and
Sergey Koren, and
Igor Antoshechkin, and
Jacob E Crawford, and
William J Glassford, and
Margaret Herre, and
Seth N Redmond, and
Noah H Rose, and
Gareth D Weedall, and
Yang Wu, and
Sanjit S Batra, and
Carlos A Brito-Sierra, and
Steven D Buckingham, and
Corey L Campbell, and
Saki Chan, and
Eric Cox, and
Benjamin R Evans, and
Thanyalak Fansiri, and
Igor Filipović, and
Albin Fontaine, and
Andrea Gloria-Soria, and
Richard Hall, and
Vinita S Joardar, and
Andrew K Jones, and
Raissa G G Kay, and
Vamsi K Kodali, and
Joyce Lee, and
Gareth J Lycett, and
Sara N Mitchell, and
Jill Muehling, and
Michael R Murphy, and
Arina D Omer, and
Frederick A Partridge, and
Paul Peluso, and
Aviva Presser Aiden, and
Vidya Ramasamy, and
Gordana Rašić, and
Sourav Roy, and
Karla Saavedra-Rodriguez, and
Shruti Sharan, and
Atashi Sharma, and
Melissa Laird Smith, and
Joe Turner, and
Allison M Weakley, and
Zhilei Zhao, and
Omar S Akbari, and
William C Black, and
Han Cao, and
Alistair C Darby, and
Catherine A Hill, and
J Spencer Johnston, and
Terence D Murphy, and
Alexander S Raikhel, and
David B Sattelle, and
Igor V Sharakhov, and
Bradley J White, and
Li Zhao, and
Erez Lieberman Aiden, and
Richard S Mann, and
Louis Lambrechts, and
Jeffrey R Powell, and
Maria V Sharakhova, and
Zhijian Tu, and
Hugh M Robertson, and
Carolyn S McBride, and
Alex R Hastie, and
Jonas Korlach, and
Daniel E Neafsey, and
Adam M Phillippy, and
Leslie B Vosshall
August 2021,
BMC developmental biology,
Benjamin J Matthews, and
Olga Dudchenko, and
Sarah B Kingan, and
Sergey Koren, and
Igor Antoshechkin, and
Jacob E Crawford, and
William J Glassford, and
Margaret Herre, and
Seth N Redmond, and
Noah H Rose, and
Gareth D Weedall, and
Yang Wu, and
Sanjit S Batra, and
Carlos A Brito-Sierra, and
Steven D Buckingham, and
Corey L Campbell, and
Saki Chan, and
Eric Cox, and
Benjamin R Evans, and
Thanyalak Fansiri, and
Igor Filipović, and
Albin Fontaine, and
Andrea Gloria-Soria, and
Richard Hall, and
Vinita S Joardar, and
Andrew K Jones, and
Raissa G G Kay, and
Vamsi K Kodali, and
Joyce Lee, and
Gareth J Lycett, and
Sara N Mitchell, and
Jill Muehling, and
Michael R Murphy, and
Arina D Omer, and
Frederick A Partridge, and
Paul Peluso, and
Aviva Presser Aiden, and
Vidya Ramasamy, and
Gordana Rašić, and
Sourav Roy, and
Karla Saavedra-Rodriguez, and
Shruti Sharan, and
Atashi Sharma, and
Melissa Laird Smith, and
Joe Turner, and
Allison M Weakley, and
Zhilei Zhao, and
Omar S Akbari, and
William C Black, and
Han Cao, and
Alistair C Darby, and
Catherine A Hill, and
J Spencer Johnston, and
Terence D Murphy, and
Alexander S Raikhel, and
David B Sattelle, and
Igor V Sharakhov, and
Bradley J White, and
Li Zhao, and
Erez Lieberman Aiden, and
Richard S Mann, and
Louis Lambrechts, and
Jeffrey R Powell, and
Maria V Sharakhova, and
Zhijian Tu, and
Hugh M Robertson, and
Carolyn S McBride, and
Alex R Hastie, and
Jonas Korlach, and
Daniel E Neafsey, and
Adam M Phillippy, and
Leslie B Vosshall
December 2019,
PLoS neglected tropical diseases,
Benjamin J Matthews, and
Olga Dudchenko, and
Sarah B Kingan, and
Sergey Koren, and
Igor Antoshechkin, and
Jacob E Crawford, and
William J Glassford, and
Margaret Herre, and
Seth N Redmond, and
Noah H Rose, and
Gareth D Weedall, and
Yang Wu, and
Sanjit S Batra, and
Carlos A Brito-Sierra, and
Steven D Buckingham, and
Corey L Campbell, and
Saki Chan, and
Eric Cox, and
Benjamin R Evans, and
Thanyalak Fansiri, and
Igor Filipović, and
Albin Fontaine, and
Andrea Gloria-Soria, and
Richard Hall, and
Vinita S Joardar, and
Andrew K Jones, and
Raissa G G Kay, and
Vamsi K Kodali, and
Joyce Lee, and
Gareth J Lycett, and
Sara N Mitchell, and
Jill Muehling, and
Michael R Murphy, and
Arina D Omer, and
Frederick A Partridge, and
Paul Peluso, and
Aviva Presser Aiden, and
Vidya Ramasamy, and
Gordana Rašić, and
Sourav Roy, and
Karla Saavedra-Rodriguez, and
Shruti Sharan, and
Atashi Sharma, and
Melissa Laird Smith, and
Joe Turner, and
Allison M Weakley, and
Zhilei Zhao, and
Omar S Akbari, and
William C Black, and
Han Cao, and
Alistair C Darby, and
Catherine A Hill, and
J Spencer Johnston, and
Terence D Murphy, and
Alexander S Raikhel, and
David B Sattelle, and
Igor V Sharakhov, and
Bradley J White, and
Li Zhao, and
Erez Lieberman Aiden, and
Richard S Mann, and
Louis Lambrechts, and
Jeffrey R Powell, and
Maria V Sharakhova, and
Zhijian Tu, and
Hugh M Robertson, and
Carolyn S McBride, and
Alex R Hastie, and
Jonas Korlach, and
Daniel E Neafsey, and
Adam M Phillippy, and
Leslie B Vosshall
March 2019,
Cadernos de saude publica,
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Olga Dudchenko, and
Sarah B Kingan, and
Sergey Koren, and
Igor Antoshechkin, and
Jacob E Crawford, and
William J Glassford, and
Margaret Herre, and
Seth N Redmond, and
Noah H Rose, and
Gareth D Weedall, and
Yang Wu, and
Sanjit S Batra, and
Carlos A Brito-Sierra, and
Steven D Buckingham, and
Corey L Campbell, and
Saki Chan, and
Eric Cox, and
Benjamin R Evans, and
Thanyalak Fansiri, and
Igor Filipović, and
Albin Fontaine, and
Andrea Gloria-Soria, and
Richard Hall, and
Vinita S Joardar, and
Andrew K Jones, and
Raissa G G Kay, and
Vamsi K Kodali, and
Joyce Lee, and
Gareth J Lycett, and
Sara N Mitchell, and
Jill Muehling, and
Michael R Murphy, and
Arina D Omer, and
Frederick A Partridge, and
Paul Peluso, and
Aviva Presser Aiden, and
Vidya Ramasamy, and
Gordana Rašić, and
Sourav Roy, and
Karla Saavedra-Rodriguez, and
Shruti Sharan, and
Atashi Sharma, and
Melissa Laird Smith, and
Joe Turner, and
Allison M Weakley, and
Zhilei Zhao, and
Omar S Akbari, and
William C Black, and
Han Cao, and
Alistair C Darby, and
Catherine A Hill, and
J Spencer Johnston, and
Terence D Murphy, and
Alexander S Raikhel, and
David B Sattelle, and
Igor V Sharakhov, and
Bradley J White, and
Li Zhao, and
Erez Lieberman Aiden, and
Richard S Mann, and
Louis Lambrechts, and
Jeffrey R Powell, and
Maria V Sharakhova, and
Zhijian Tu, and
Hugh M Robertson, and
Carolyn S McBride, and
Alex R Hastie, and
Jonas Korlach, and
Daniel E Neafsey, and
Adam M Phillippy, and
Leslie B Vosshall
January 2017,
PLoS currents,
