BIOMAT Database Logo BIOMAT Database Logo

Altered acylation of erythrocyte phospholipids in alcoholism. 1988

M Gastaldi, and B Lerique, and T Feugère, and J Le Petit-Thévenin, and O Nobili, and J Boyer
Unité de Recherches sur la Physio-pathologie des Régulations du Métabolisme Lipidique, INSERM U.260, Faculté de Médecine, Marseille, France.

The composition and metabolism of erythrocyte lipids were studied in 10 chronic alcoholic patients within 48 hr after discontinuation of alcohol intake and in 10 nonalcoholic control subjects. Chronic alcoholism produced no change in contents of cholesterol, total phospholipids, and proportions of phosphatidylcholine and phosphatidylethanolamine in erythrocyte phospholipids. The mean values of the rates of acylation of phosphatidylcholine and phosphatidylethanolamine with oleic acid were increased respectively by 59% (p less than 0.001) and 38% (p less than 0.05) as compared with the controls. There was no correlation between acylation rates and mean cellular volumes. Increases in acylation rates normalized over several weeks after alcohol withdrawal and were not related to a direct effect of alcohol on the intact erythrocyte, suggesting that these alterations result from ethanol-induced changes in the membrane during erythrocyte formation. The increased rates of acylation might modify the remodeling of the lipid matrix and thereby the membrane function.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010713 Phosphatidylcholines Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety. Choline Phosphoglycerides,Choline Glycerophospholipids,Phosphatidyl Choline,Phosphatidyl Cholines,Phosphatidylcholine,Choline, Phosphatidyl,Cholines, Phosphatidyl,Glycerophospholipids, Choline,Phosphoglycerides, Choline
D010714 Phosphatidylethanolamines Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids. Cephalin,Cephalins,Ethanolamine Phosphoglyceride,Ethanolamine Phosphoglycerides,Ethanolamineglycerophospholipids,Phosphoglyceride, Ethanolamine,Phosphoglycerides, Ethanolamine
D010743 Phospholipids Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system. Phosphatides,Phospholipid
D002784 Cholesterol The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Epicholesterol
D004910 Erythrocyte Membrane The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS. Erythrocyte Ghost,Red Cell Cytoskeleton,Red Cell Ghost,Erythrocyte Cytoskeleton,Cytoskeleton, Erythrocyte,Cytoskeleton, Red Cell,Erythrocyte Cytoskeletons,Erythrocyte Ghosts,Erythrocyte Membranes,Ghost, Erythrocyte,Ghost, Red Cell,Membrane, Erythrocyte,Red Cell Cytoskeletons,Red Cell Ghosts
D004912 Erythrocytes Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN. Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

M Gastaldi, and B Lerique, and T Feugère, and J Le Petit-Thévenin, and O Nobili, and J Boyer
[Changes in the fatty acid composition of erythrocyte membrane phospholipids in alcoholism].
February 1988, Gematologiia i transfuziologiia,
M Gastaldi, and B Lerique, and T Feugère, and J Le Petit-Thévenin, and O Nobili, and J Boyer
Fatty acylation of erythrocyte proteins.
October 1989, Biochemical Society transactions,
M Gastaldi, and B Lerique, and T Feugère, and J Le Petit-Thévenin, and O Nobili, and J Boyer
N-Acylation of ethanolamine phospholipids in canine myocardium.
August 1982, Biochimica et biophysica acta,
M Gastaldi, and B Lerique, and T Feugère, and J Le Petit-Thévenin, and O Nobili, and J Boyer
[Erythrocyte morphometry in alcoholism].
September 1989, Anales de medicina interna (Madrid, Spain : 1984),
M Gastaldi, and B Lerique, and T Feugère, and J Le Petit-Thévenin, and O Nobili, and J Boyer
Fatty acid content of plasma lipids and erythrocyte phospholipids are altered following burn injury.
July 2001, Lipids,
M Gastaldi, and B Lerique, and T Feugère, and J Le Petit-Thévenin, and O Nobili, and J Boyer
[Erythrocyte phospholipids in Duchenne's myopathy].
December 1979, La Nouvelle presse medicale,
M Gastaldi, and B Lerique, and T Feugère, and J Le Petit-Thévenin, and O Nobili, and J Boyer
Increased erythrocyte calcium in alcoholism.
October 1982, Journal of clinical pharmacology,
M Gastaldi, and B Lerique, and T Feugère, and J Le Petit-Thévenin, and O Nobili, and J Boyer
Acyl-CoA dependent acylation of phospholipids in the chloroplast envelope.
May 2000, Biochimica et biophysica acta,
M Gastaldi, and B Lerique, and T Feugère, and J Le Petit-Thévenin, and O Nobili, and J Boyer
Erythrocyte membrane phospholipids in psychotic patients.
October 1993, Psychiatry research,
M Gastaldi, and B Lerique, and T Feugère, and J Le Petit-Thévenin, and O Nobili, and J Boyer
Erythrocyte phospholipids in Duchenne muscular dystrophy.
January 1977, Clinica chimica acta; international journal of clinical chemistry,
Copied contents to your clipboard!