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Multidrug resistance (MDR) refers to a complex phenotype that describes a number of features characterized primarily by resistance to a wide range of structurally unrelated drugs. In this paper we investigated the relationship between drug resistance and resistance to NK-mediated cytotoxicity. Studies with two independently selected multidrug-resistant cell lines indicated that increased drug resistance was associated with both an increased resistance to NK-mediated cytotoxicity and increased levels of membrane P-glycoprotein expression. This resistance to cytotoxicity appears to result partly from an alteration in the membrane structure of the target cells inasmuch as there was a reduction in effector:target cell recognition. Resistance to NK-mediated cytotoxicity should be included with the numerous pleiotropic changes associated with the multidrug resistance phenotype.
G Woods, and
L A Lund, and
M Naik, and
V Ling, and
A Ochi
February 1993,
Transplantation proceedings,
G Woods, and
L A Lund, and
M Naik, and
V Ling, and
A Ochi
March 1983,
Proceedings of the National Academy of Sciences of the United States of America,
G Woods, and
L A Lund, and
M Naik, and
V Ling, and
A Ochi
May 2012,
Cancer letters,
G Woods, and
L A Lund, and
M Naik, and
V Ling, and
A Ochi
July 1989,
Cancer,
G Woods, and
L A Lund, and
M Naik, and
V Ling, and
A Ochi
November 2000,
Human immunology,
G Woods, and
L A Lund, and
M Naik, and
V Ling, and
A Ochi
May 1982,
Immunology letters,
G Woods, and
L A Lund, and
M Naik, and
V Ling, and
A Ochi
March 2005,
Experimental hematology,
G Woods, and
L A Lund, and
M Naik, and
V Ling, and
A Ochi
January 1988,
Annals of the New York Academy of Sciences,
G Woods, and
L A Lund, and
M Naik, and
V Ling, and
A Ochi
November 1982,
Journal of immunology (Baltimore, Md. : 1950),
G Woods, and
L A Lund, and
M Naik, and
V Ling, and
A Ochi
March 1983,
International journal of cancer,
