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Mucus is the first line of innate mucosal defense in all mammals. Gel‑forming mucins control the rheological properties of mucus hydrogels by forming a network in which hydrophilic and hydrophobic regions coexist, and it has been revealed that the network is formed through both covalent links and reversible links such as hydrophobic interactions in order to modulate the structure as a function of the physiological necessities. Here, we review the structure and functions of the mucus in terms of the gel-forming mucins protein-protein interactions, also called interactome. Since it is difficult to characterize the low energy reversible interactions due to their dependence on physico-chemical environment, their role is not well understood. Still, they constitute a promising target to counteract mucus abnormalities observed in mucus-associated diseases.
Bastien Demouveaux, and
Valérie Gouyer, and
Mylène Magnien, and
Ségolène Plet, and
Frédéric Gottrand, and
Tetsuharu Narita, and
Jean-Luc Desseyn
January 2000,
Methods in molecular biology (Clifton, N.J.),
Bastien Demouveaux, and
Valérie Gouyer, and
Mylène Magnien, and
Ségolène Plet, and
Frédéric Gottrand, and
Tetsuharu Narita, and
Jean-Luc Desseyn
October 2013,
Infection and immunity,
Bastien Demouveaux, and
Valérie Gouyer, and
Mylène Magnien, and
Ségolène Plet, and
Frédéric Gottrand, and
Tetsuharu Narita, and
Jean-Luc Desseyn
January 1978,
British medical bulletin,
Bastien Demouveaux, and
Valérie Gouyer, and
Mylène Magnien, and
Ségolène Plet, and
Frédéric Gottrand, and
Tetsuharu Narita, and
Jean-Luc Desseyn
August 2000,
Molecular biology and evolution,
Bastien Demouveaux, and
Valérie Gouyer, and
Mylène Magnien, and
Ségolène Plet, and
Frédéric Gottrand, and
Tetsuharu Narita, and
Jean-Luc Desseyn
October 2007,
Proceedings of the National Academy of Sciences of the United States of America,
Bastien Demouveaux, and
Valérie Gouyer, and
Mylène Magnien, and
Ségolène Plet, and
Frédéric Gottrand, and
Tetsuharu Narita, and
Jean-Luc Desseyn
April 2007,
Histology and histopathology,
Bastien Demouveaux, and
Valérie Gouyer, and
Mylène Magnien, and
Ségolène Plet, and
Frédéric Gottrand, and
Tetsuharu Narita, and
Jean-Luc Desseyn
January 2000,
Methods in molecular biology (Clifton, N.J.),
Bastien Demouveaux, and
Valérie Gouyer, and
Mylène Magnien, and
Ségolène Plet, and
Frédéric Gottrand, and
Tetsuharu Narita, and
Jean-Luc Desseyn
November 2023,
The FEBS journal,
Bastien Demouveaux, and
Valérie Gouyer, and
Mylène Magnien, and
Ségolène Plet, and
Frédéric Gottrand, and
Tetsuharu Narita, and
Jean-Luc Desseyn
June 2017,
Proceedings of the National Academy of Sciences of the United States of America,
Bastien Demouveaux, and
Valérie Gouyer, and
Mylène Magnien, and
Ségolène Plet, and
Frédéric Gottrand, and
Tetsuharu Narita, and
Jean-Luc Desseyn
May 1994,
Biochemical Society transactions,
