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Sixty lepromatous or borderline lepromatous patients were submitted to immunotherapy with a mixture of autoclaved Mycobacterium leprae and BCG. The histopathologic findings in skin biopsy specimens taken before and after immunotherapy were evaluated independently by six histopathologists in a workshop setting. Their pooled observations on diagnosis and classification were analyzed to assess the histopathologic changes following various periods of immunotherapy. Expressing the results as the average value of five to six independent observations, there were changes in classification of reversal or upgrading toward the tuberculoid end of the leprosy spectrum in 90.5% of the patients initially classified as lepromatous (LL), and in 83.3% of those initially classified as borderline lepromatous (BL). The histopathologic findings amply support the clinical, bacteriologic and immunological changes following immunotherapy from LL or BL, to BL, mid-borderline (BB) or even borderline tuberculoid (BT) leprosy.
W M Meyers, and
A C McDougall, and
R N Fleury, and
R Neves, and
O Reyes, and
C H Binford
January 2014,
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
W M Meyers, and
A C McDougall, and
R N Fleury, and
R Neves, and
O Reyes, and
C H Binford
January 1986,
Nihon Rai Gakkai zasshi,
W M Meyers, and
A C McDougall, and
R N Fleury, and
R Neves, and
O Reyes, and
C H Binford
June 1991,
The American journal of tropical medicine and hygiene,
W M Meyers, and
A C McDougall, and
R N Fleury, and
R Neves, and
O Reyes, and
C H Binford
June 1983,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
W M Meyers, and
A C McDougall, and
R N Fleury, and
R Neves, and
O Reyes, and
C H Binford
August 1999,
The Journal of dermatology,
W M Meyers, and
A C McDougall, and
R N Fleury, and
R Neves, and
O Reyes, and
C H Binford
February 1992,
Lancet (London, England),
W M Meyers, and
A C McDougall, and
R N Fleury, and
R Neves, and
O Reyes, and
C H Binford
December 1988,
Leprosy review,
W M Meyers, and
A C McDougall, and
R N Fleury, and
R Neves, and
O Reyes, and
C H Binford
January 1995,
Clinical and experimental immunology,
W M Meyers, and
A C McDougall, and
R N Fleury, and
R Neves, and
O Reyes, and
C H Binford
January 1976,
Repura. Leprosy,
W M Meyers, and
A C McDougall, and
R N Fleury, and
R Neves, and
O Reyes, and
C H Binford
December 1987,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
