BIOMAT Database Logo BIOMAT Database Logo

[Biosynthesis of folic acid in Eimeria tenella (Coccidia)]. 1978

V I Zaĭonts, and M V Krylov, and V I Loskot, and A I Kirillov

The inhibitory analysis has shown that E. tenella does not include ready folic acid into metabolic process but synthesizes its metabolite, 7:8-dihydrofolic acid (DHFA), from its precursor, para-aminobenzoic acid (PABA), which enters the host's organism. PABA can be fully substituted in the process of metabolism by sulphadimesin (SD) at the molar ratio PABA: SD=1: 16.7. As a concurrent antagonist of PABA SD is 6 times stronger in the parasite-host system of Coccidia than in bacteria in cultural medium. The increase in PABA content in relation to SD more than 1: 16.7 intensifies the viability of Coccidia that is expressed in higher lethality of chicks, which reaches its maximum at PABA : SD=1 : 1.25. A further increase in the content of PABA does not affect the host's lethality. The decrease in PABA in relation to SD lower than 1 : 16.7 reduces the viability of Coccidia. Nucleic bases G, A transforming in the organism into corresponding nucleotids and aminoacids, 1-metionin and glycine, which are the products of biosynthesis with a participation of DHFA, do not stimulate the viability of E. tenella that apparently is associated with the non-capability of the host to assimilate timidin.

UI MeSH Term Description Entries
D010129 4-Aminobenzoic Acid An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS. PABA,p-Aminobenzoic Acid,para-Aminobenzoic Acid,4-Aminobenzoic Acid, Potassium Salt,Aminobenzoic Acid (USP),Epit Vit,Epitelplast,Hachemina,Magnesium para-Aminobenzoate,Pabasan,Paraminan,Paraminol,Potaba,Potassium 4-Aminobenzoate,Potassium Aminobenzoate,4 Aminobenzoic Acid,4 Aminobenzoic Acid, Potassium Salt,4-Aminobenzoate, Potassium,Aminobenzoate, Potassium,Potassium 4 Aminobenzoate,p Aminobenzoic Acid,para Aminobenzoic Acid,para-Aminobenzoate, Magnesium
D002645 Chickens Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA. Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D003048 Coccidiosis Protozoan infection found in animals and man. It is caused by several different genera of COCCIDIA. Besnoitiasis,Besnoitiosis,Besnoitiases,Besnoitioses,Coccidioses
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004539 Eimeria A genus of protozoan parasites of the subclass COCCIDIA. Various species are parasitic in the epithelial cells of the liver and intestines of man and other animals. Eimerias
D005492 Folic Acid A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. Pteroylglutamic Acid,Vitamin M,Folacin,Folate,Folic Acid, (D)-Isomer,Folic Acid, (DL)-Isomer,Folic Acid, Calcium Salt (1:1),Folic Acid, Monopotassium Salt,Folic Acid, Monosodium Salt,Folic Acid, Potassium Salt,Folic Acid, Sodium Salt,Folvite,Vitamin B9,B9, Vitamin
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013424 Sulfanilamides Compounds based on 4-aminobenzenesulfonamide. The '-anil-' part of the name refers to aniline. Sulphanilamides

Related Publications

V I Zaĭonts, and M V Krylov, and V I Loskot, and A I Kirillov
Thymidylic acid synthesis in Eimeria tenella (Coccidia) cultured in vitro.
May 1974, The Journal of protozoology,
V I Zaĭonts, and M V Krylov, and V I Loskot, and A I Kirillov
Sexual differentiation in Eimeria tenella (Sporozoa: Coccidia).
February 1977, The Journal of parasitology,
V I Zaĭonts, and M V Krylov, and V I Loskot, and A I Kirillov
Gametogony of eimeria tenella (coccidia) in cell cultures.
February 1969, Science (New York, N.Y.),
V I Zaĭonts, and M V Krylov, and V I Loskot, and A I Kirillov
Cytochemical observations on Eimeria tenella (Coccidia) propagated in cell culture.
June 1972, The Journal of parasitology,
V I Zaĭonts, and M V Krylov, and V I Loskot, and A I Kirillov
Effects of monoclonal IgG antibodies on Eimeria tenella (coccidia) sporozoites.
August 1983, The Journal of parasitology,
V I Zaĭonts, and M V Krylov, and V I Loskot, and A I Kirillov
Peptides associated with monensin resistance in sporozoites of Eimeria tenella (Coccidia).
April 1994, The Journal of parasitology,
V I Zaĭonts, and M V Krylov, and V I Loskot, and A I Kirillov
Drug resistance in coccidia: a robenidine-resistant strain of eimeria tenella.
October 1977, Canadian journal of comparative medicine : Revue canadienne de medecine comparee,
V I Zaĭonts, and M V Krylov, and V I Loskot, and A I Kirillov
Eimeria tenella (Sporozoa, Coccidia): Gametogony following a single asexual generation.
April 1976, Science (New York, N.Y.),
V I Zaĭonts, and M V Krylov, and V I Loskot, and A I Kirillov
Variant proteins associated with ionophore resistance in sporozoites of Eimeria tenella (Coccidia).
January 1993, Parasitology research,
V I Zaĭonts, and M V Krylov, and V I Loskot, and A I Kirillov
[Electron microscope studies of the nutrition of coccidia in cell cultures (Eimeria tenella)].
January 1968, Zeitschrift fur Parasitenkunde (Berlin, Germany),
Copied contents to your clipboard!