BIOMAT Database Logo BIOMAT Database Logo

Protein expression in the liver and blood serum in chickens in response to Salmonella Enteritidis infection. 2018

Ondrej Polansky, and Zuzana Seidlerova, and Marcela Faldynova, and Frantisek Sisak, and Ivan Rychlik
Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic. Electronic address: polansky@vri.cz.

Events occurring in the chicken caecum following Salmonella Enteritidis infection are relatively well-described. However, mechanisms of the immune response and defence beyond the intestinal tract are less well-described. In this study, we therefore determined changes in protein abundance in the liver and blood serum in response to S. Enteritidis infection using the unbiased approach of shotgun proteomics. Complement and coagulation cascades, TNF signalling, antigen processing and presentation was activated in the liver following infection with S. Enteritidis. Chicken proteins that decreased in the liver were involved in glycolysis, the citrate cycle, oxidative phosphorylation and fatty acid metabolism. No functional category was significantly activated or suppressed in the serum. Concerning individual proteins, VNN1, SAA, AVD, SERPINA3, SERPINB10, AGT, MRP126 or CP increased in abundance both in the liver and serum. MT4, MT3, PTGDS, GLRX and TGM4, though highly inducible in the liver, did not increase in the serum. PIGR, SERPINF2 and IGJ increased in the serum but not in the liver. SERPINA4, apoAIV, CLEC3B, SERPINF1, HRG, AHSG and ALB decreased both in the liver and serum. Avidin-like LOC431660, THRSP, GATM, GGACT, ACOX1, ALDOB or FABP7 decreased in the liver but not in the serum. Finally, CKM, CKB, PLTP, COMP, IGFALS, AMY1A or SERPIND1 decreased in the serum after S. Enteritidis infection but not in the liver. Differently abundant proteins characterise the chicken's response to infection and can be also used as markers of chicken health status.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D011201 Poultry Diseases Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild. Disease, Poultry,Diseases, Poultry,Poultry Disease
D002432 Cecum The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX. Cecums
D002645 Chickens Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA. Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D000209 Acute-Phase Proteins Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers. Acute Phase Reactant,Acute-Phase Glycoprotein,Acute-Phase Reactant,Acute-Phase Reactants,Proteins, Acute-Phase,Reactants, Acute-Phase,Acute-Phase Glycoproteins,Acute-Phase Protein,Acute Phase Glycoprotein,Acute Phase Glycoproteins,Acute Phase Protein,Acute Phase Proteins,Acute Phase Reactants,Glycoprotein, Acute-Phase,Glycoproteins, Acute-Phase,Phase Reactant, Acute,Protein, Acute-Phase,Proteins, Acute Phase,Reactant, Acute Phase,Reactant, Acute-Phase,Reactants, Acute Phase
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012477 Salmonella enteritidis A serotype of Salmonella enterica which is an etiologic agent of gastroenteritis in man and other animals. Salmonella enterica serovar enteritidis
D012481 Salmonella Infections, Animal Infections in animals with bacteria of the genus SALMONELLA. Animal Salmonella Infection,Animal Salmonella Infections,Infection, Animal Salmonella,Infections, Animal Salmonella,Salmonella Infection, Animal
D017951 Antigen Presentation The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989) Antigen Processing,Antigen Presentations,Antigen Processings
D040901 Proteomics The systematic study of the complete complement of proteins (PROTEOME) of organisms. Peptidomics

Related Publications

Ondrej Polansky, and Zuzana Seidlerova, and Marcela Faldynova, and Frantisek Sisak, and Ivan Rychlik
Serological response of chickens to Salmonella enteritidis infection.
February 1990, Epidemiology and infection,
Ondrej Polansky, and Zuzana Seidlerova, and Marcela Faldynova, and Frantisek Sisak, and Ivan Rychlik
Salmonella enteritidis infection in broiler chickens.
February 1988, The Veterinary record,
Ondrej Polansky, and Zuzana Seidlerova, and Marcela Faldynova, and Frantisek Sisak, and Ivan Rychlik
Experimental infection of chickens with Salmonella enteritidis.
March 1991, Avian pathology : journal of the W.V.P.A,
Ondrej Polansky, and Zuzana Seidlerova, and Marcela Faldynova, and Frantisek Sisak, and Ivan Rychlik
Effect of Eimeria tenella infection on Salmonella enteritidis infection in chickens.
January 1995, Poultry science,
Ondrej Polansky, and Zuzana Seidlerova, and Marcela Faldynova, and Frantisek Sisak, and Ivan Rychlik
Splenic microRNA Expression Profiles and Integration Analyses Involved in Host Responses to Salmonella enteritidis Infection in Chickens.
January 2017, Frontiers in cellular and infection microbiology,
Ondrej Polansky, and Zuzana Seidlerova, and Marcela Faldynova, and Frantisek Sisak, and Ivan Rychlik
Gene Expression Profiles of Chicken Embryo Fibroblasts in Response to Salmonella Enteritidis Infection.
January 2015, PloS one,
Ondrej Polansky, and Zuzana Seidlerova, and Marcela Faldynova, and Frantisek Sisak, and Ivan Rychlik
Eimeria tenella infection induces recrudescence of previous Salmonella enteritidis infection in chickens.
November 1995, Poultry science,
Ondrej Polansky, and Zuzana Seidlerova, and Marcela Faldynova, and Frantisek Sisak, and Ivan Rychlik
Association of SPOP Expression with the Immune Response to Salmonella Infection in Chickens.
February 2020, Animals : an open access journal from MDPI,
Ondrej Polansky, and Zuzana Seidlerova, and Marcela Faldynova, and Frantisek Sisak, and Ivan Rychlik
Allelic variation in TLR4 is linked to resistance to Salmonella Enteritidis infection in chickens.
July 2017, Poultry science,
Ondrej Polansky, and Zuzana Seidlerova, and Marcela Faldynova, and Frantisek Sisak, and Ivan Rychlik
Response to Salmonella enteritidis infection by the immunocompromised avian host.
April 1995, Poultry science,
Copied contents to your clipboard!