Iridoid Derivatives with Cytotoxic Activity from Pedicularis uliginosa Bunge. 2019

Li-Fang Liu, and Ming-Jun Yao, and Man-Yu Li, and Xiao-Zhen Wu, and Cheng-Shan Yuan
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China.

Three new iridoids, rel-(4aR,7S,7aS)-7-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carbaldehyde (1), 1-methoxy-7-methyl-1,3,5,6-tetrahydrocyclopenta[c]pyran-4-carbaldehyde (2), and rel-(1R,4S,4aS,7R,7aR)-7-methylhexahydro-1,4-(epoxymethano)cyclopenta[c]pyran-3(1H)-one (3), together with seven known analogues, were isolated from the 95 % EtOH extract of the whole plants of Pedicularis uliginosa Bunge. Their structures were elucidated via extensive NMR spectroscopy and mass spectral data. In terms of inhibitory effects on human tumor cells, compounds 1, 2, 6, 7, and 8 exhibited better inhibitory activities against ACHN cells than the positive control (vinblastine).

UI MeSH Term Description Entries
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D032262 Pedicularis A plant genus of the family Orobanchaceae. Members contain phenylpropanoid glycosides and iridoids. Pediculari
D039823 Iridoids A type of MONOTERPENES, derived from geraniol. They have the general form of cyclopentanopyran, but in some cases, one of the rings is broken as in the case of secoiridoid. They are different from the similarly named iridals (TRITERPENES). Iridoid,Iridoid Derivatives,Secoiridoids,Iridoid Aglycones,Aglycones, Iridoid,Derivatives, Iridoid

Related Publications

Li-Fang Liu, and Ming-Jun Yao, and Man-Yu Li, and Xiao-Zhen Wu, and Cheng-Shan Yuan
December 1998, Planta medica,
Li-Fang Liu, and Ming-Jun Yao, and Man-Yu Li, and Xiao-Zhen Wu, and Cheng-Shan Yuan
January 1991, Phytochemistry,
Li-Fang Liu, and Ming-Jun Yao, and Man-Yu Li, and Xiao-Zhen Wu, and Cheng-Shan Yuan
January 1992, Phytochemistry,
Li-Fang Liu, and Ming-Jun Yao, and Man-Yu Li, and Xiao-Zhen Wu, and Cheng-Shan Yuan
January 1991, Phytochemistry,
Li-Fang Liu, and Ming-Jun Yao, and Man-Yu Li, and Xiao-Zhen Wu, and Cheng-Shan Yuan
January 2013, Natural product research,
Li-Fang Liu, and Ming-Jun Yao, and Man-Yu Li, and Xiao-Zhen Wu, and Cheng-Shan Yuan
May 2021, Natural product research,
Li-Fang Liu, and Ming-Jun Yao, and Man-Yu Li, and Xiao-Zhen Wu, and Cheng-Shan Yuan
June 2023, Phytochemistry,
Li-Fang Liu, and Ming-Jun Yao, and Man-Yu Li, and Xiao-Zhen Wu, and Cheng-Shan Yuan
June 1997, Planta medica,
Li-Fang Liu, and Ming-Jun Yao, and Man-Yu Li, and Xiao-Zhen Wu, and Cheng-Shan Yuan
April 2007, Archives of pharmacal research,
Li-Fang Liu, and Ming-Jun Yao, and Man-Yu Li, and Xiao-Zhen Wu, and Cheng-Shan Yuan
July 2018, Fitoterapia,
Copied contents to your clipboard!