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A phase II study of the use of colony stimulating factor derived from human urine (CSF-HU) was performed after bone marrow transplantation (BMT). Steady and rapid recovery of leukocyte and granulocyte numbers was observed. In most patients who received CSF-HU from day 1, leukocyte numbers started to increase on day 6 and monocytes and granulocytes on day 11. Significant differences in the days to recovery of leukocytes over 1 x 10(9)/l and of granulocytes over 0.5 x 10(9)/l were observed in comparison with non-randomized control patients. In some patients in whom recovery of leukocytes was delayed, CSF also seemed to be effective in increasing leukocyte numbers from 8 days after the start of administration. There was no significant difference in the rate of relapse of leukemia between the two groups. CSF-HU seems very promising as a treatment of patients after BMT by shortening the period of leukopenia or granulocytopenia.
T Masaoka, and
K Motoyoshi, and
F Takaku, and
S Kato, and
M Harada, and
Y Kodera, and
A Kanamaru, and
Y Moriyama, and
R Ohno, and
M Ohira
November 1996,
Chinese medical journal,
T Masaoka, and
K Motoyoshi, and
F Takaku, and
S Kato, and
M Harada, and
Y Kodera, and
A Kanamaru, and
Y Moriyama, and
R Ohno, and
M Ohira
September 1994,
Blood,
T Masaoka, and
K Motoyoshi, and
F Takaku, and
S Kato, and
M Harada, and
Y Kodera, and
A Kanamaru, and
Y Moriyama, and
R Ohno, and
M Ohira
July 1988,
Lancet (London, England),
T Masaoka, and
K Motoyoshi, and
F Takaku, and
S Kato, and
M Harada, and
Y Kodera, and
A Kanamaru, and
Y Moriyama, and
R Ohno, and
M Ohira
November 1989,
Gan to kagaku ryoho. Cancer & chemotherapy,
T Masaoka, and
K Motoyoshi, and
F Takaku, and
S Kato, and
M Harada, and
Y Kodera, and
A Kanamaru, and
Y Moriyama, and
R Ohno, and
M Ohira
December 1992,
Blood,
T Masaoka, and
K Motoyoshi, and
F Takaku, and
S Kato, and
M Harada, and
Y Kodera, and
A Kanamaru, and
Y Moriyama, and
R Ohno, and
M Ohira
November 1989,
Experimental hematology,
T Masaoka, and
K Motoyoshi, and
F Takaku, and
S Kato, and
M Harada, and
Y Kodera, and
A Kanamaru, and
Y Moriyama, and
R Ohno, and
M Ohira
August 1988,
Behring Institute Mitteilungen,
T Masaoka, and
K Motoyoshi, and
F Takaku, and
S Kato, and
M Harada, and
Y Kodera, and
A Kanamaru, and
Y Moriyama, and
R Ohno, and
M Ohira
November 1994,
Bone marrow transplantation,
T Masaoka, and
K Motoyoshi, and
F Takaku, and
S Kato, and
M Harada, and
Y Kodera, and
A Kanamaru, and
Y Moriyama, and
R Ohno, and
M Ohira
January 1990,
Haematology and blood transfusion,
T Masaoka, and
K Motoyoshi, and
F Takaku, and
S Kato, and
M Harada, and
Y Kodera, and
A Kanamaru, and
Y Moriyama, and
R Ohno, and
M Ohira
December 1989,
Japanese journal of clinical oncology,
