The effect of random blood transfusions on immunoglobulin production by peripheral blood mononuclear cells from uraemic patients. 1988

D Degiannis, and A M Mowat, and D Tsakiris, and J D Briggs, and B J Junor, and D M Parrott
Department of Bacteriology and Immunology, Western Infirmary, Glasgow, Scotland.

The effect of blood transfusion on humoral immunity in chronic renal failure was studied by examining immunoglobulin production in vitro, in patients awaiting renal transplantation. Pokeweed mitogen (PWM) induced IgG plaque formation was normal in non-transfused uraemic patients while both spontaneous and Staphylococcus aureus Cowan I (SAC) induced immunoglobulin production were reduced. Five to ten units of third party blood transfusion reduced PWM-driven B cell differentiation, but had no effect on SAC-induced plaque formation, while spontaneous production of immunoglobulin was either enhanced or unaffected. As it is known that the response to SAC is less affected by suppressor T cell activity than that to PWM, these differences in the inhibitory effects of blood transfusion on B cell differentiation are further evidence that transfusion may act by increasing suppressor T cell activity.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011043 Pokeweed Mitogens Proteins isolated from the roots of the pokeweed, Phytolacca americana, that agglutinate some erythrocytes, stimulate mitosis and antibody synthesis in lymphocytes, and induce activation of plasma cells. Lectins, Pokeweed,Pokeweed Lectin,Pokeweed Lectins,Pokeweed Mitogen,Pokeweed Mitogen Isolectin,Isolectin, Pokeweed Mitogen,Lectin, Pokeweed,Mitogen Isolectin, Pokeweed,Mitogen, Pokeweed,Mitogens, Pokeweed
D001803 Blood Transfusion The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed) Blood Transfusions,Transfusion, Blood,Transfusions, Blood
D003208 Concanavalin A A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
D005260 Female Females
D006462 Hemolytic Plaque Technique A method to identify and enumerate cells that are synthesizing ANTIBODIES against ANTIGENS or HAPTENS conjugated to sheep RED BLOOD CELLS. The sheep red blood cells surrounding cells secreting antibody are lysed by added COMPLEMENT producing a clear zone of HEMOLYSIS. (From Illustrated Dictionary of Immunology, 3rd ed) Jerne's Plaque Technique,Hemolytic Plaque Technic,Jerne's Plaque Technic,Hemolytic Plaque Technics,Hemolytic Plaque Techniques,Jerne Plaque Technic,Jerne Plaque Technique,Jernes Plaque Technic,Jernes Plaque Technique,Plaque Technic, Hemolytic,Plaque Technic, Jerne's,Plaque Technics, Hemolytic,Plaque Technique, Hemolytic,Plaque Technique, Jerne's,Plaque Techniques, Hemolytic,Technic, Hemolytic Plaque,Technic, Jerne's Plaque,Technics, Hemolytic Plaque,Technique, Hemolytic Plaque,Technique, Jerne's Plaque,Techniques, Hemolytic Plaque
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

D Degiannis, and A M Mowat, and D Tsakiris, and J D Briggs, and B J Junor, and D M Parrott
August 1996, European journal of haematology,
D Degiannis, and A M Mowat, and D Tsakiris, and J D Briggs, and B J Junor, and D M Parrott
November 1996, Clinical and experimental immunology,
D Degiannis, and A M Mowat, and D Tsakiris, and J D Briggs, and B J Junor, and D M Parrott
February 1984, Clinical and experimental immunology,
D Degiannis, and A M Mowat, and D Tsakiris, and J D Briggs, and B J Junor, and D M Parrott
February 2006, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology,
D Degiannis, and A M Mowat, and D Tsakiris, and J D Briggs, and B J Junor, and D M Parrott
October 1999, Experimental hematology,
D Degiannis, and A M Mowat, and D Tsakiris, and J D Briggs, and B J Junor, and D M Parrott
June 2000, Experimental hematology,
D Degiannis, and A M Mowat, and D Tsakiris, and J D Briggs, and B J Junor, and D M Parrott
April 1999, Immunology,
D Degiannis, and A M Mowat, and D Tsakiris, and J D Briggs, and B J Junor, and D M Parrott
June 1986, Hiroshima journal of medical sciences,
D Degiannis, and A M Mowat, and D Tsakiris, and J D Briggs, and B J Junor, and D M Parrott
January 1994, Acta haematologica,
D Degiannis, and A M Mowat, and D Tsakiris, and J D Briggs, and B J Junor, and D M Parrott
September 1984, Infection and immunity,
Copied contents to your clipboard!