Endocrine disorders associated with hepatitis C virus chronic infection. 2018

Michele Colaci, and Lorenzo Malatino, and Alessandro Antonelli, and Poupak Fallahi, and Dilia Giuggioli, and Clodoveo Ferri
Internal Medicine Unit, Cannizzaro Hospital, Department of Clinical and Experimental Medicine, University of Catania, Via Messina, 829, 95100, Catania, Italy. michele.colaci@unict.it.

The term "HCV syndrome" encompasses several organ- and systemic pathophysiological states, which often recognize autoimmunity or neoplastic evolution in their pathophysiology, as well as chronic HCV infection as trigger. The clinical features of HCV patients are heterogenous, and may include endocrine or metabolic disorders, namely autoimmune thyroiditis, type 2 diabetes mellitus, and erectile/sexual dysfunctions. In this review, we summarize current knowledge on the endocrine/metabolic diseases associated with chronic HCV infection, focusing on the main concepts emerged in the recent literature in this field. The application of this knowledge in everyday clinical practice may be relevant, in order to reinforce a holistic vision of the patient with chronic HCV infection, stimulating in turn a multi-disciplinary approach, thus increasing the probability of early diagnosis, more effective treatments, and a better prognostic outcome.

UI MeSH Term Description Entries
D007037 Hypothyroidism A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction. Central Hypothyroidism,Primary Hypothyroidism,Secondary Hypothyroidism,TSH Deficiency,Thyroid-Stimulating Hormone Deficiency,Central Hypothyroidisms,Deficiency, TSH,Deficiency, Thyroid-Stimulating Hormone,Hormone Deficiency, Thyroid-Stimulating,Hypothyroidism, Central,Hypothyroidism, Primary,Hypothyroidism, Secondary,Hypothyroidisms,Primary Hypothyroidisms,Secondary Hypothyroidisms,TSH Deficiencies,Thyroid Stimulating Hormone Deficiency,Thyroid-Stimulating Hormone Deficiencies
D007172 Erectile Dysfunction The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction. Impotence,Male Impotence,Male Sexual Impotence,Dysfunction, Erectile,Impotence, Male,Impotence, Male Sexual,Sexual Impotence, Male
D008297 Male Males
D003924 Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non-Insulin-Dependent,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,MODY,Maturity-Onset Diabetes Mellitus,NIDDM,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Noninsulin-Dependent,Diabetes Mellitus, Type II,Maturity-Onset Diabetes,Noninsulin-Dependent Diabetes Mellitus,Type 2 Diabetes,Type 2 Diabetes Mellitus,Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Slow Onset,Diabetes, Maturity-Onset,Diabetes, Type 2,Ketosis-Resistant Diabetes Mellitus,Maturity Onset Diabetes,Maturity Onset Diabetes Mellitus,Non-Insulin-Dependent Diabetes Mellitus,Noninsulin Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013967 Thyroiditis, Autoimmune Inflammatory disease of the THYROID GLAND due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-CELLS and thyroid AUTOANTIBODIES. The clinical signs can range from HYPOTHYROIDISM to THYROTOXICOSIS depending on the type of autoimmune thyroiditis. Autoimmune Thyroiditis,Thyroiditis, Lymphocytic,Thyroiditis, Lymphomatous,Autoimmune Thyroiditides,Lymphocytic Thyroiditides,Lymphocytic Thyroiditis,Lymphomatous Thyroiditides,Lymphomatous Thyroiditis,Thyroiditides, Autoimmune,Thyroiditides, Lymphocytic,Thyroiditides, Lymphomatous
D019698 Hepatitis C, Chronic INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS. Chronic Hepatitis C

Related Publications

Michele Colaci, and Lorenzo Malatino, and Alessandro Antonelli, and Poupak Fallahi, and Dilia Giuggioli, and Clodoveo Ferri
February 2000, Annales de medecine interne,
Michele Colaci, and Lorenzo Malatino, and Alessandro Antonelli, and Poupak Fallahi, and Dilia Giuggioli, and Clodoveo Ferri
November 1996, Mayo Clinic proceedings,
Michele Colaci, and Lorenzo Malatino, and Alessandro Antonelli, and Poupak Fallahi, and Dilia Giuggioli, and Clodoveo Ferri
October 2011, The Journal of rheumatology,
Michele Colaci, and Lorenzo Malatino, and Alessandro Antonelli, and Poupak Fallahi, and Dilia Giuggioli, and Clodoveo Ferri
January 2000, Gastroenterologia y hepatologia,
Michele Colaci, and Lorenzo Malatino, and Alessandro Antonelli, and Poupak Fallahi, and Dilia Giuggioli, and Clodoveo Ferri
June 2006, Thyroid : official journal of the American Thyroid Association,
Michele Colaci, and Lorenzo Malatino, and Alessandro Antonelli, and Poupak Fallahi, and Dilia Giuggioli, and Clodoveo Ferri
September 2011, Journal of clinical neuromuscular disease,
Michele Colaci, and Lorenzo Malatino, and Alessandro Antonelli, and Poupak Fallahi, and Dilia Giuggioli, and Clodoveo Ferri
November 2009, Liver international : official journal of the International Association for the Study of the Liver,
Michele Colaci, and Lorenzo Malatino, and Alessandro Antonelli, and Poupak Fallahi, and Dilia Giuggioli, and Clodoveo Ferri
December 2017, Revista espanola de sanidad penitenciaria,
Michele Colaci, and Lorenzo Malatino, and Alessandro Antonelli, and Poupak Fallahi, and Dilia Giuggioli, and Clodoveo Ferri
July 1997, Circulation,
Michele Colaci, and Lorenzo Malatino, and Alessandro Antonelli, and Poupak Fallahi, and Dilia Giuggioli, and Clodoveo Ferri
April 1996, Gastroenterologia y hepatologia,
Copied contents to your clipboard!