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N-Propyl-N-nitrosourea (PNU) was proved to be a strong leukemogen, which induces myelogenous leukemia or thymic lymphoma in rats. BUF/Mna rats and F344 rats were the strain most susceptible to thymic lymphomagenic activity of PNU. In addition, F1 rats between BUF/Mna and WKY rats were also susceptible to PNU-lymphomagenic activity. In the present experiment, karyotypes of 31 thymic lymphomas induced by PNU in BUF/Mna rats and in F1 rats between BUF/Mna and WKY rats were analysed for chromosomal abnormalities. Although no specific chromosomal abnormalities were observed throughout all lymphomas, del(11q) and dup(2q) were observed frequently in BUF/Mna rat lymphomas. Breakpoints and/or fusion-points were frequently observed in chromosome 11, followed by chromosomes 2, 5 and 6. Trisomy of chromosome 7, on which c-myc oncogene is mapped, was observed in seven cases, and monosomy of chromosomes 12, 18, 19, 20 and X was seen in seven or eight cases each, though these changes were generally observed in minor cell population in each case.
T Ogiu, and
K R Utsumi, and
H Fukami, and
M Matsuyama
July 1995,
Japanese journal of cancer research : Gann,
T Ogiu, and
K R Utsumi, and
H Fukami, and
M Matsuyama
December 1992,
Thymus,
T Ogiu, and
K R Utsumi, and
H Fukami, and
M Matsuyama
December 1982,
Cancer genetics and cytogenetics,
T Ogiu, and
K R Utsumi, and
H Fukami, and
M Matsuyama
November 1989,
Acta pathologica japonica,
T Ogiu, and
K R Utsumi, and
H Fukami, and
M Matsuyama
September 1985,
Acta pathologica japonica,
T Ogiu, and
K R Utsumi, and
H Fukami, and
M Matsuyama
December 1981,
Cancer genetics and cytogenetics,
T Ogiu, and
K R Utsumi, and
H Fukami, and
M Matsuyama
January 1983,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
T Ogiu, and
K R Utsumi, and
H Fukami, and
M Matsuyama
December 2009,
Zhongguo shi yan xue ye xue za zhi,
T Ogiu, and
K R Utsumi, and
H Fukami, and
M Matsuyama
March 2003,
Cancer science,
T Ogiu, and
K R Utsumi, and
H Fukami, and
M Matsuyama
January 1988,
Leukemia research,
