Biomaterial Database

Antiparasitic Activity of Auranofin against Pathogenic Naegleria fowleri. 2019

Nathan Peroutka-Bigus, and Bryan H Bellaire

Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, College of Veterinary Medicine, Ames, Iowa, 50011.

We report that the gold containing antirheumatoid drug auranofin is amoebicidal against human pathogenic Naegleria fowleri. Treatment of N. fowleri cultures at biologically relevant concentrations of 0.75-3.0 μg/ml auranofin reduced amoeba counts, metabolic activity, and increased cell permeability. These results suggest that the addition of auranofin may benefit the treatment of N. fowleri-infected patients afflicted by the rapidly fatal disease primary amoebic meningoencephalitis.

UI	MeSH Term	Description	Entries
D000562	Amebiasis	Infection with any of various amebae. It is an asymptomatic carrier state in most individuals, but diseases ranging from chronic, mild diarrhea to fulminant dysentery may occur.	Abscess, Amebic,Acanthamebiasis,Ameboma,Amoebiasis,Iodamoebiasis,Acanthamoeba Infection,Balamuthia Infection,Abscesses, Amebic,Acanthamebiases,Acanthamoeba Infections,Amebiases,Amebic Abscess,Amebic Abscesses,Amoebiases,Balamuthia Infections,Infection, Acanthamoeba,Infection, Balamuthia,Iodamoebiases
D000563	Amebicides	Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal.	Amoebicides
D001310	Auranofin	An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious.	Crisinor,Ridaura,Ridauran,SK&F D 39162,SK&F-39162,SK&F 39162,SK&F39162
D016848	Naegleria fowleri	A species of parasitic protozoa having both an ameboid and flagellate stage in its life cycle. Infection with this pathogen produces PRIMARY AMEBIC MENINGOENCEPHALITIS.	Naegleria fowlerus,fowlerus, Naegleria
D020808	Central Nervous System Protozoal Infections	Infections of the brain, spinal cord, or meninges by single celled organisms of the former subkingdom known as protozoa. The central nervous system may be the primary or secondary site of protozoal infection. These diseases may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.	CNS Protozoal Infections,Cerebral Protozoal Infections,Meningoencephalitis, Protozoal,Protozoal Infections, Central Nervous System,Acanthamoeba Meningoencephalitis,Amebic Meningoencephalitis,Balamuthia mandrillaris CNS Infection,Balamuthia mandrillaris Meningoencephalitis,Infection, Central Nervous System, Protozoal,Infections, Protozoal, Central Nervous System,Naegleria fowleri Infection,Naegleria fowleri Meningoencephalitis,Primary Amebic Meningoencephalitis,Protozoal Infections, Cerebral,Protozoal Meningoencephalitis,Sappinia diploidea Meningoencephalitis,Acanthamoeba Meningoencephalitides,Amebic Meningoencephalitides,Amebic Meningoencephalitides, Primary,Amebic Meningoencephalitis, Primary,Balamuthia mandrillaris Meningoencephalitides,CNS Protozoal Infection,Cerebral Protozoal Infection,Infection, CNS Protozoal,Infection, Cerebral Protozoal,Infection, Naegleria fowleri,Infections, CNS Protozoal,Meningoencephalitides, Acanthamoeba,Meningoencephalitides, Amebic,Meningoencephalitides, Balamuthia mandrillaris,Meningoencephalitides, Naegleria fowleri,Meningoencephalitides, Primary Amebic,Meningoencephalitides, Protozoal,Meningoencephalitides, Sappinia diploidea,Meningoencephalitis, Acanthamoeba,Meningoencephalitis, Amebic,Meningoencephalitis, Balamuthia mandrillaris,Meningoencephalitis, Naegleria fowleri,Meningoencephalitis, Primary Amebic,Meningoencephalitis, Sappinia diploidea,Naegleria fowleri Infections,Naegleria fowleri Meningoencephalitides,Primary Amebic Meningoencephalitides,Protozoal Infection, CNS,Protozoal Infection, Cerebral,Protozoal Infections, CNS,Protozoal Meningoencephalitides,Sappinia diploidea Meningoencephalitides