Biomaterial Database

Susceptibility of Plasmodium falciparum to chloroquine and mefloquine in Somalia. 1988

M Warsame, and M Lebbad, and S Ali, and W H Wernsdorfer, and A Björkman

Department of Infectious Diseases, Karolinska Institute, Roslagstull Hospital, Stockholm, Sweden.

A field study was conducted in the Malable area, in Somalia, to assess the susceptibility of Plasmodium falciparum to chloroquine and mefloquine. The in vivo response of P. falciparum to standard therapeutic regimen of chloroquine was studied in 16 children (1-12 years) using the standard WHO in vivo field test. All subjects were parasite free by day 3 and no recrudescence occurred during a 7-d follow-up. In the 24 h micro in vitro tests for chloroquine, 29 of 39 tests performed were successful. Of the 29 isolates, 3 showed distinct resistance and 2 were borderline. The drug concentration yielding 99% (EC99) inhibition was 1.64 x 10(-6) M, indicating low grade resistance. For mefloquine, 11 of 20 tests gave interpretable results and were sensitive, although with some heterogeneity. The EC50 and EC99 of 0.24 x 10(-6) M and 1.31 x 10(-6) M respectively indicate sensitivity.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D008288	Malaria	A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.	Marsh Fever,Plasmodium Infections,Remittent Fever,Infections, Plasmodium,Paludism,Fever, Marsh,Fever, Remittent,Infection, Plasmodium,Plasmodium Infection
D010963	Plasmodium falciparum	A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.	Plasmodium falciparums,falciparums, Plasmodium
D011804	Quinolines
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D002738	Chloroquine	The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.	Aralen,Arechine,Arequin,Chingamin,Chlorochin,Chloroquine Sulfate,Chloroquine Sulphate,Khingamin,Nivaquine,Sulfate, Chloroquine,Sulphate, Chloroquine
D004351	Drug Resistance	Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.	Resistance, Drug
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths