BIOMAT Database Logo BIOMAT Database Logo

Low doses of recombinant interleukin-2 enhance delayed type hypersensitivity to PPD in mice infected with Mycobacterium bovis-BCG and fed a diet supplemented with vitamin A acetate. 1988

F Ferraro, and M Mattei, and V Colizzi
Department of Biology, II University of Rome/Italy.

Mice infected intravenously with high doses of M. bovis, strain BCG, showed a marked impairment of delayed-type hypersensitivity to PPD evaluated in vivo as skin test and in vitro as splenocyte blast transformation. Furthermore, this state of unresponsiveness is partially reversed either by the intraperitoneal injection of high doses of IL-2 or by feeding mice a diet supplemented with vitamin A acetate (VAA) at least 6 weeks before the BCG injection. This paper shows that low doses of recombinant IL-2 together with a supplementation of VAA in the diet at the moment of BCG infection is sufficient to induce in mice a positive skin reaction and blast transformation to PPD.

UI MeSH Term Description Entries
D006968 Hypersensitivity, Delayed An increased reactivity to specific antigens mediated not by antibodies but by sensitized T CELLS. Hypersensitivity, Tuberculin-Type,Hypersensitivity, Type IV,Tuberculin-Type Hypersensitivity,Type IV Hypersensitivity,Delayed Hypersensitivity,Delayed Hypersensitivities,Hypersensitivity, Tuberculin Type,Tuberculin Type Hypersensitivity,Tuberculin-Type Hypersensitivities,Type IV Hypersensitivities
D007376 Interleukin-2 A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes. IL-2,Lymphocyte Mitogenic Factor,T-Cell Growth Factor,TCGF,IL2,Interleukin II,Interleukine 2,RU 49637,RU-49637,Ro-23-6019,Ro-236019,T-Cell Stimulating Factor,Thymocyte Stimulating Factor,Interleukin 2,Mitogenic Factor, Lymphocyte,RU49637,Ro 23 6019,Ro 236019,Ro236019,T Cell Growth Factor,T Cell Stimulating Factor
D008808 Mice, Inbred CBA An inbred strain of mouse that is widely used in BIOMEDICAL RESEARCH. Mice, CBA,Mouse, CBA,Mouse, Inbred CBA,CBA Mice,CBA Mice, Inbred,CBA Mouse,CBA Mouse, Inbred,Inbred CBA Mice,Inbred CBA Mouse
D009163 Mycobacterium bovis The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis. BCG,Calmette-Guerin Bacillus
D011994 Recombinant Proteins Proteins prepared by recombinant DNA technology. Biosynthetic Protein,Biosynthetic Proteins,DNA Recombinant Proteins,Recombinant Protein,Proteins, Biosynthetic,Proteins, Recombinant DNA,DNA Proteins, Recombinant,Protein, Biosynthetic,Protein, Recombinant,Proteins, DNA Recombinant,Proteins, Recombinant,Recombinant DNA Proteins,Recombinant Proteins, DNA
D004224 Diterpenes Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate. Diterpene,Diterpenes, Cembrane,Diterpenes, Labdane,Diterpenoid,Labdane Diterpene,Norditerpene,Norditerpenes,Norditerpenoid,Cembranes,Diterpenoids,Labdanes,Norditerpenoids,Cembrane Diterpenes,Diterpene, Labdane,Labdane Diterpenes
D000084562 Retinyl Esters A carboxylic ester of retinol formed by condensation of the hydroxy group of retinol with a carboxy group. All-Trans-Retinyl Ester,All-Trans-Retinyl Esters,Retinyl Ester,All Trans Retinyl Ester,All Trans Retinyl Esters,Ester, All-Trans-Retinyl,Ester, Retinyl
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014374 Tuberculin Test One of several skin tests to determine past or present tuberculosis infection. A purified protein derivative of the tubercle bacilli, called tuberculin, is introduced into the skin by scratch, puncture, or interdermal injection. Test, Tuberculin,Tests, Tuberculin,Tuberculin Tests
D014376 Tuberculosis Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS. Koch's Disease,Kochs Disease,Mycobacterium tuberculosis Infection,Infection, Mycobacterium tuberculosis,Infections, Mycobacterium tuberculosis,Koch Disease,Mycobacterium tuberculosis Infections,Tuberculoses

Related Publications

F Ferraro, and M Mattei, and V Colizzi
Augmentation of interleukin-2 production and delayed hypersensitivity in mice infected with Mycobacterium bovis and fed a diet supplemented with vitamin A acetate.
May 1985, Infection and immunity,
F Ferraro, and M Mattei, and V Colizzi
Tuberculin hypersensitivity hepatitis in mice infected with Mycobacterium bovis (BCG).
October 1981, The American journal of pathology,
F Ferraro, and M Mattei, and V Colizzi
Induction of suppressor T cells in delayed-type hypersensitivity to Mycobacterium bovis BCG in low-responder mice.
May 1980, Infection and immunity,
F Ferraro, and M Mattei, and V Colizzi
Interleukin-6 production in Mycobacterium bovis BCG-infected mice.
October 1991, Cellular immunology,
F Ferraro, and M Mattei, and V Colizzi
Enhancement of delayed-type hypersensitivity to Trypanosoma cruzi in mice treated with Mycobacterium bovis BCG and cyclophosphamide.
March 1981, Infection and immunity,
F Ferraro, and M Mattei, and V Colizzi
Recombinant interleukin-2 limits the replication of Mycobacterium lepraemurium and Mycobacterium bovis BCG in mice.
January 1988, Lymphokine research,
F Ferraro, and M Mattei, and V Colizzi
Recombinant interleukin-2 limits the replication of Mycobacterium lepraemurium and Mycobacterium bovis BCG in mice.
March 1988, Infection and immunity,
F Ferraro, and M Mattei, and V Colizzi
Delayed-type hypersensitivity to a recombinant mycobacterial antigen, MPB64, in guinea pigs sensitized to Mycobacterium tuberculosis or Mycobacterium bovis BCG.
February 1995, Journal of leukocyte biology,
F Ferraro, and M Mattei, and V Colizzi
Local adoptive transfer of delayed-type hypersensitivity to tuberculin from M. bovis (BCG) infected mice.
January 1989, Folia biologica,
F Ferraro, and M Mattei, and V Colizzi
Difference in antigen-presenting ability of macrophages between high- and low-responder mice in delayed-type hypersensitivity to Mycobacterium bovis BCG.
January 1980, Infection and immunity,
Copied contents to your clipboard!