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Several possibilities for the prevention of adhesions were checked in animal experiments. In rats adhesions were produced by a standardized operative procedure. For the prevention of adhesions an artificial ascites with normal saline solution or Dextran was tried. To maintain ascites an intraperitoneal catheter was left in place for the first three post-operative days and refilled. The proteolytic effect of Chymotrypsin, the proteinase inhibitor Trasylol and of Glucocorticoids was investigated. All three drugs showed a definite therapeutic effect. In 45-50% of the rats adhesions were prevented. A combination of Trasylol, Glucocorticoids and Dextran prevented adhesions in 65% of the animals. When the ascites was maintained for four days 80% of the animals remained free of adhesions.
V Lehmann, and
L Memmel, and
H Freudrich
October 1974,
Zeitschrift fur Orthopadie und ihre Grenzgebiete,
V Lehmann, and
L Memmel, and
H Freudrich
January 1981,
Journal de gynecologie, obstetrique et biologie de la reproduction,
V Lehmann, and
L Memmel, and
H Freudrich
January 1967,
Zentralblatt fur Chirurgie,
V Lehmann, and
L Memmel, and
H Freudrich
December 1979,
Die Pharmazie,
V Lehmann, and
L Memmel, and
H Freudrich
July 1981,
MMW, Munchener medizinische Wochenschrift,
V Lehmann, and
L Memmel, and
H Freudrich
January 1981,
Zentralblatt fur Chirurgie,
V Lehmann, and
L Memmel, and
H Freudrich
January 1981,
Unfallchirurgie,
V Lehmann, and
L Memmel, and
H Freudrich
March 1977,
Klinische Monatsblatter fur Augenheilkunde,
V Lehmann, and
L Memmel, and
H Freudrich
April 1974,
Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology,
V Lehmann, and
L Memmel, and
H Freudrich
May 1974,
MMW, Munchener medizinische Wochenschrift,
