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Small doses of endotoxin have been shown to induce pulmonary microvascular injury in sheep, possibly by the action of granulocytes. Eglin, a potent inhibitor of neutrophil elastase, was tested in an ovine model of endotoxemia. The experiment was performed in 12 unanesthetized chronically instrumented sheep with a lung lymph preparation. Endotoxin (S. abort. equii) was infused at 24 ng/(kg x h) with application of 20 mg/kg eglin 1 h before endotoxin in the treatment group and followed by 5 mg/(kg x h). No significant improvement due to the treatment was seen for either cardiovascular status (pulmonary and systemic vascular resistance) or permeability changes in the lung (lymph flow and lymph/plasma protein ratio), although sufficient eglin concentrations were achieved in plasma and lymph. The lack of an effect of eglin might be because higher concentrations are needed to block elastase-like activity of ovine granulocytes or because of a minor role for neutrophil elastase in this shock model.
H Redl, and
G Schlag, and
C Vogl, and
A Schiesser, and
E Paul, and
M Thurnher, and
W Junger, and
L D Traber, and
D L Traber
March 1992,
Circulatory shock,
H Redl, and
G Schlag, and
C Vogl, and
A Schiesser, and
E Paul, and
M Thurnher, and
W Junger, and
L D Traber, and
D L Traber
January 1985,
European journal of respiratory diseases. Supplement,
H Redl, and
G Schlag, and
C Vogl, and
A Schiesser, and
E Paul, and
M Thurnher, and
W Junger, and
L D Traber, and
D L Traber
January 1986,
European journal of respiratory diseases. Supplement,
H Redl, and
G Schlag, and
C Vogl, and
A Schiesser, and
E Paul, and
M Thurnher, and
W Junger, and
L D Traber, and
D L Traber
January 1985,
Progress in clinical and biological research,
H Redl, and
G Schlag, and
C Vogl, and
A Schiesser, and
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M Thurnher, and
W Junger, and
L D Traber, and
D L Traber
June 1989,
Journal of molecular biology,
H Redl, and
G Schlag, and
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A Schiesser, and
E Paul, and
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W Junger, and
L D Traber, and
D L Traber
January 2018,
Shock (Augusta, Ga.),
H Redl, and
G Schlag, and
C Vogl, and
A Schiesser, and
E Paul, and
M Thurnher, and
W Junger, and
L D Traber, and
D L Traber
January 2007,
International journal of immunopathology and pharmacology,
H Redl, and
G Schlag, and
C Vogl, and
A Schiesser, and
E Paul, and
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L D Traber, and
D L Traber
January 2007,
The Annals of thoracic surgery,
H Redl, and
G Schlag, and
C Vogl, and
A Schiesser, and
E Paul, and
M Thurnher, and
W Junger, and
L D Traber, and
D L Traber
January 1985,
Circulatory shock,
H Redl, and
G Schlag, and
C Vogl, and
A Schiesser, and
E Paul, and
M Thurnher, and
W Junger, and
L D Traber, and
D L Traber
January 1989,
Progress in clinical and biological research,
