-transparent.png){kind=logo}
The neurotoxic potential of benzylpenicillin administered intravenously as a continuous infusion was studied in rabbits with experimental Escherichia coli meningitis. As controls a group of rabbits was injected with saline into the cisterna magna. The concentrations of benzylpenicillin in serum, CSF and brain tissue fluid were studied at onset of epileptogenic electroencephalographic activity (thirteen rabbits) or convulsions (ten rabbits), with a previously developed method for neurotoxicity studies. E. coli meningitis did not increase the neurotoxicity of benzylpenicillin, despite high concentrations of the drug in both CSF and brain tissue fluid. The intracisternal injection of saline in the control group produced slight pleocytosis in some rabbits indicating some degree of damage of the blood-CSF barrier.
S E Schliamser, and
H Bolander, and
H Kourtopoulos, and
J Sigaard, and
S R Norrby
March 1986,
Antimicrobial agents and chemotherapy,
S E Schliamser, and
H Bolander, and
H Kourtopoulos, and
J Sigaard, and
S R Norrby
July 1999,
Antimicrobial agents and chemotherapy,
S E Schliamser, and
H Bolander, and
H Kourtopoulos, and
J Sigaard, and
S R Norrby
April 1981,
Infection and immunity,
S E Schliamser, and
H Bolander, and
H Kourtopoulos, and
J Sigaard, and
S R Norrby
July 1981,
Antimicrobial agents and chemotherapy,
S E Schliamser, and
H Bolander, and
H Kourtopoulos, and
J Sigaard, and
S R Norrby
September 1985,
Antimicrobial agents and chemotherapy,
S E Schliamser, and
H Bolander, and
H Kourtopoulos, and
J Sigaard, and
S R Norrby
January 1997,
Antimicrobial agents and chemotherapy,
S E Schliamser, and
H Bolander, and
H Kourtopoulos, and
J Sigaard, and
S R Norrby
November 2001,
Antimicrobial agents and chemotherapy,
S E Schliamser, and
H Bolander, and
H Kourtopoulos, and
J Sigaard, and
S R Norrby
January 1983,
Chemotherapy,
S E Schliamser, and
H Bolander, and
H Kourtopoulos, and
J Sigaard, and
S R Norrby
January 1989,
Hindustan antibiotics bulletin,
S E Schliamser, and
H Bolander, and
H Kourtopoulos, and
J Sigaard, and
S R Norrby
January 1991,
Folia microbiologica,
