Hydatidiform molar pregnancy following assisted reproduction. 2019

M Nickkho-Amiry, and G Horne, and M Akhtar, and R Mathur, and D R Brison
Department of Obstetrics and Gynaecology, Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton-under-lyne, OL6 9RW, UK. mamiry@me.com.

BACKGROUND The use of assisted reproduction techniques (ART) is increasing; however, reports of molar pregnancy following ART remain scarce. Currently, the Human Fertility and Embryology Authority (HFEA) collates data on the molar pregnancies that have resulted through the use of ART. Recently, they have indicated that they will no longer collect these data. OBJECTIVE This paper aimed to examine the incidence of molar pregnancy amongst patients undergoing assisted reproduction. METHODS We contacted HFEA and placed a request under the Freedom of Information Act (2000) for the number of molar pregnancies that resulted from fresh/frozen embryo transfer since HFEA started collecting data in 1991 to February 2018. We also asked how many patients who had suffered a molar pregnancy went on to have a normal pregnancy and how many had subsequent molar pregnancies, in subsequent treatment cycles. RESULTS Between 68 and 76 molar pregnancies occurred within this period using ART (n = 274,655). The incidence of molar pregnancy using fresh intracytoplasmic sperm injection (ICSI) (1/4302) and fresh in vitro fertilisation (IVF) (1/4333) was similar. The risk of recurrence of molar pregnancy following a previous molar was higher following ART compared to spontaneous conceptions. CONCLUSIONS The use of ICSI should be protective against triploidy; however, the retrospective data suggests that molar pregnancy is not eliminated with the use of ART. It is pertinent to continue to record this data, through the gestational trophoblastic disease centres, in order to ensure no further increase in incidence, appropriate follow-up, and transparency in communication.

UI MeSH Term Description Entries
D008297 Male Males
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D002824 Chorionic Villi Threadlike vascular projections of the chorion. Chorionic villi may be free or embedded within the DECIDUA forming the site for exchange of substances between fetal and maternal blood (PLACENTA). Placental Villi,Labyrinth of the Placenta,Labyrinthine Placenta,Placental Labyrinth Layer,Chorionic Villus,Labyrinth Layer, Placental,Placental Labyrinth Layers,Placental Villus,Villi, Chorionic,Villi, Placental,Villus, Chorionic,Villus, Placental
D005260 Female Females
D005307 Fertilization in Vitro An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro. Test-Tube Fertilization,Fertilizations in Vitro,In Vitro Fertilization,Test-Tube Babies,Babies, Test-Tube,Baby, Test-Tube,Fertilization, Test-Tube,Fertilizations, Test-Tube,In Vitro Fertilizations,Test Tube Babies,Test Tube Fertilization,Test-Tube Baby,Test-Tube Fertilizations
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006828 Hydatidiform Mole Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype. Molar Pregnancy,Pregnancy, Molar,Hydatid Mole,Hydatidiform Mole, Complete,Hydatidiform Mole, Partial,Complete Hydatidiform Mole,Complete Hydatidiform Moles,Hydatid Moles,Hydatidiform Moles,Hydatidiform Moles, Complete,Hydatidiform Moles, Partial,Molar Pregnancies,Mole, Complete Hydatidiform,Mole, Hydatid,Mole, Hydatidiform,Mole, Partial Hydatidiform,Moles, Complete Hydatidiform,Moles, Hydatid,Moles, Hydatidiform,Moles, Partial Hydatidiform,Partial Hydatidiform Mole,Partial Hydatidiform Moles,Pregnancies, Molar
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D057885 Triploidy Polyploidy with three sets of chromosomes. Triploidy in humans are 69XXX, 69XXY, and 69XYY. It is associated with HOLOPROSENCEPHALY; ABNORMALITIES, MULTIPLE; PARTIAL HYDATIDIFORM MOLE; and MISCARRAGES. Triploid,Triploidies,Triploids

Related Publications

M Nickkho-Amiry, and G Horne, and M Akhtar, and R Mathur, and D R Brison
March 2020, Journal of assisted reproduction and genetics,
M Nickkho-Amiry, and G Horne, and M Akhtar, and R Mathur, and D R Brison
December 2003, The Australian & New Zealand journal of obstetrics & gynaecology,
M Nickkho-Amiry, and G Horne, and M Akhtar, and R Mathur, and D R Brison
November 2020, Gynecologic oncology reports,
M Nickkho-Amiry, and G Horne, and M Akhtar, and R Mathur, and D R Brison
March 2011, Human fertility (Cambridge, England),
M Nickkho-Amiry, and G Horne, and M Akhtar, and R Mathur, and D R Brison
January 2003, BJOG : an international journal of obstetrics and gynaecology,
M Nickkho-Amiry, and G Horne, and M Akhtar, and R Mathur, and D R Brison
January 2008, Gynecologic and obstetric investigation,
M Nickkho-Amiry, and G Horne, and M Akhtar, and R Mathur, and D R Brison
January 2021, Academic pathology,
M Nickkho-Amiry, and G Horne, and M Akhtar, and R Mathur, and D R Brison
December 1983, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
M Nickkho-Amiry, and G Horne, and M Akhtar, and R Mathur, and D R Brison
November 2012, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology,
M Nickkho-Amiry, and G Horne, and M Akhtar, and R Mathur, and D R Brison
December 1976, British medical journal,
Copied contents to your clipboard!