BIOMAT Database Logo BIOMAT Database Logo

Novel contribution to clubfoot pathogenesis: The possible role of extracellular matrix proteins. 2019

Adam Eckhardt, and Tomas Novotny, and Martina Doubkova, and Lucia Hronkova, and Ludek Vajner, and Statis Pataridis, and Daniel Hadraba, and Lucie Kulhava, and Martin Plencner, and Jarmila Knitlova, and Jana Liskova, and Jiri Uhlik, and Marie Zaloudikova, and David Vondrasek, and Ivan Miksik, and Martin Ostadal
Institute of Physiology of the Czech Academy of Sciences, v.v.i Videnska 1083, Prague, Czech Republic.

Idiopathic pes equinovarus (clubfoot) is a congenital deformity of the feet and lower legs. Clubfoot belongs to a group of fibro-proliferative disorders but its origin remains unknown. Our study aimed to achieve the first complex proteomic comparison of clubfoot contracted tissue of the foot (medial side; n = 16), with non-contracted tissue (lateral side; n = 13). We used label-free mass spectrometry quantification and immunohistochemistry. Seven proteins were observed to be significantly upregulated in the medial side (asporin, collagen type III, V, and VI, versican, tenascin-C, and transforming growth factor beta induced protein) and four in the lateral side (collagen types XII and XIV, fibromodulin, and cartilage intermediate layer protein 2) of the clubfoot. Comparison of control samples from cadavers brought only two different protein concentrations (collagen types I and VI). We also revealed pathological calcification and intracellular positivity of transforming growth factor beta only in the contracted tissue of clubfoot. Most of the 11 differently expressed proteins are strongly related to the extracellular matrix architecture and we assume that they may play specific roles in the pathogenesis of this deformity. These proteins seem to be promising targets for future investigations and treatment of this disease. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

UI MeSH Term Description Entries
D008297 Male Males
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D002114 Calcinosis Pathologic deposition of calcium salts in tissues. Calcification, Pathologic,Calcinosis, Tumoral,Microcalcification,Microcalcinosis,Pathologic Calcification,Calcinoses,Calcinoses, Tumoral,Microcalcifications,Microcalcinoses,Tumoral Calcinoses,Tumoral Calcinosis
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D003025 Clubfoot A deformed foot in which the foot is plantarflexed, inverted, and adducted. Equinovarus,Talipes Equinovarus,Clubfeet,Clubfeet, Congenital,Clubfoot, Congenital,Congenital Talipes Equinovarus,Pie Torcido,Congenital Clubfeet,Congenital Clubfoot,Pie Torcidos,Talipes Equinovarus, Congenital
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013058 Mass Spectrometry An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers. Mass Spectroscopy,Spectrometry, Mass,Spectroscopy, Mass,Spectrum Analysis, Mass,Analysis, Mass Spectrum,Mass Spectrum Analysis,Analyses, Mass Spectrum,Mass Spectrum Analyses,Spectrum Analyses, Mass
D016212 Transforming Growth Factor beta A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins. Bone-Derived Transforming Growth Factor,Platelet Transforming Growth Factor,TGF-beta,Milk Growth Factor,TGFbeta,Bone Derived Transforming Growth Factor,Factor, Milk Growth,Growth Factor, Milk

Related Publications

Adam Eckhardt, and Tomas Novotny, and Martina Doubkova, and Lucia Hronkova, and Ludek Vajner, and Statis Pataridis, and Daniel Hadraba, and Lucie Kulhava, and Martin Plencner, and Jarmila Knitlova, and Jana Liskova, and Jiri Uhlik, and Marie Zaloudikova, and David Vondrasek, and Ivan Miksik, and Martin Ostadal
Pathogenesis of onchocercal dermatitis: possible role of parasite proteases and autoantibodies to extracellular matrix proteins.
September 1994, Experimental parasitology,
Adam Eckhardt, and Tomas Novotny, and Martina Doubkova, and Lucia Hronkova, and Ludek Vajner, and Statis Pataridis, and Daniel Hadraba, and Lucie Kulhava, and Martin Plencner, and Jarmila Knitlova, and Jana Liskova, and Jiri Uhlik, and Marie Zaloudikova, and David Vondrasek, and Ivan Miksik, and Martin Ostadal
Root resorption: the possible role of extracellular matrix proteins.
August 2004, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics,
Adam Eckhardt, and Tomas Novotny, and Martina Doubkova, and Lucia Hronkova, and Ludek Vajner, and Statis Pataridis, and Daniel Hadraba, and Lucie Kulhava, and Martin Plencner, and Jarmila Knitlova, and Jana Liskova, and Jiri Uhlik, and Marie Zaloudikova, and David Vondrasek, and Ivan Miksik, and Martin Ostadal
The Role of Fibrogenesis and Extracellular Matrix Proteins in the Pathogenesis of Graves' Ophthalmopathy.
March 2024, International journal of molecular sciences,
Adam Eckhardt, and Tomas Novotny, and Martina Doubkova, and Lucia Hronkova, and Ludek Vajner, and Statis Pataridis, and Daniel Hadraba, and Lucie Kulhava, and Martin Plencner, and Jarmila Knitlova, and Jana Liskova, and Jiri Uhlik, and Marie Zaloudikova, and David Vondrasek, and Ivan Miksik, and Martin Ostadal
The congenital clubfoot - immunohistological analysis of the extracellular matrix.
January 2018, Orthopedic research and reviews,
Adam Eckhardt, and Tomas Novotny, and Martina Doubkova, and Lucia Hronkova, and Ludek Vajner, and Statis Pataridis, and Daniel Hadraba, and Lucie Kulhava, and Martin Plencner, and Jarmila Knitlova, and Jana Liskova, and Jiri Uhlik, and Marie Zaloudikova, and David Vondrasek, and Ivan Miksik, and Martin Ostadal
Contribution of the extracellular matrix to growth properties of cells from a preneoplastic outgrowth: possible role of hyaluronic acid.
January 1987, Experimental cell biology,
Adam Eckhardt, and Tomas Novotny, and Martina Doubkova, and Lucia Hronkova, and Ludek Vajner, and Statis Pataridis, and Daniel Hadraba, and Lucie Kulhava, and Martin Plencner, and Jarmila Knitlova, and Jana Liskova, and Jiri Uhlik, and Marie Zaloudikova, and David Vondrasek, and Ivan Miksik, and Martin Ostadal
Phosphorylation of Extracellular Bone Matrix Proteins and Its Contribution to Bone Fragility.
December 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
Adam Eckhardt, and Tomas Novotny, and Martina Doubkova, and Lucia Hronkova, and Ludek Vajner, and Statis Pataridis, and Daniel Hadraba, and Lucie Kulhava, and Martin Plencner, and Jarmila Knitlova, and Jana Liskova, and Jiri Uhlik, and Marie Zaloudikova, and David Vondrasek, and Ivan Miksik, and Martin Ostadal
Extracellular matrix remodelling in the endometrium and its possible relevance to the pathogenesis of endometriosis.
January 1998, Human reproduction update,
Adam Eckhardt, and Tomas Novotny, and Martina Doubkova, and Lucia Hronkova, and Ludek Vajner, and Statis Pataridis, and Daniel Hadraba, and Lucie Kulhava, and Martin Plencner, and Jarmila Knitlova, and Jana Liskova, and Jiri Uhlik, and Marie Zaloudikova, and David Vondrasek, and Ivan Miksik, and Martin Ostadal
The Role of Extracellular Matrix Proteins in Breast Cancer.
February 2022, Journal of clinical medicine,
Adam Eckhardt, and Tomas Novotny, and Martina Doubkova, and Lucia Hronkova, and Ludek Vajner, and Statis Pataridis, and Daniel Hadraba, and Lucie Kulhava, and Martin Plencner, and Jarmila Knitlova, and Jana Liskova, and Jiri Uhlik, and Marie Zaloudikova, and David Vondrasek, and Ivan Miksik, and Martin Ostadal
The Functional Role of Extracellular Matrix Proteins in Cancer.
January 2022, Cancers,
Adam Eckhardt, and Tomas Novotny, and Martina Doubkova, and Lucia Hronkova, and Ludek Vajner, and Statis Pataridis, and Daniel Hadraba, and Lucie Kulhava, and Martin Plencner, and Jarmila Knitlova, and Jana Liskova, and Jiri Uhlik, and Marie Zaloudikova, and David Vondrasek, and Ivan Miksik, and Martin Ostadal
A novel view to varicose veins pathogenesis: Proteomic profiling suggests a pivotal role of extracellular matrix degradation.
February 2024, Phlebology,
Copied contents to your clipboard!