Biomaterial Database

[Recent knowledge and hypotheses on the significance of the HLA-D region in rheumatoid arthritis]. 1988

G Haberhauer

2. Medizinischen Abteilung im Kaiser-Franz-Josef-Spital der Stadt Wien.

Rheumatoid arthritis (RA) may result from an interaction between genetic and environmental factors. There is a well documented association between RA and the serologically defined class II MHC antigen haplotype DR4-DRw53-DQw3. Cellular HLA typing reveals five Dw subtypes (Dw4, 10, 13, 14, 15) of this haplotype. DNA coding for this Dw-subtypes occurs in the third hypervariable region (3. HVR) of the DR beta 1 domain suggesting, that this part of the molecule is recognized by T cells. Relatively circumscribed amino acid changes in this 3. HVR, which contains an alpha-helical structure, may result in immune response changes. Susceptibility to RA may be due to related epitopes found in non-Dw10 subtypes of DR4, as well as in DR1 alleles. Studies, using T cell clones specific for the Dw14 subtype of DR4 found Dw14-associated epitopes in 100% (!) also on non-DR4 haplotypes, in the population with RA. Typing with primed lymphocytes may give rise to the association of HLA and RA.

UI	MeSH Term	Description	Entries
D005787	Gene Frequency	The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.	Allele Frequency,Genetic Equilibrium,Equilibrium, Genetic,Allele Frequencies,Frequencies, Allele,Frequencies, Gene,Frequency, Allele,Frequency, Gene,Gene Frequencies
D006681	HLA-D Antigens	Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.	Antigens, HLA-D,Class II Human Antigens,HLA-Dw Antigens,Human Class II Antigens,Ia-Like Antigens, Human,Immune Response-Associated Antigens, Human,Immune-Associated Antigens, Human,Immune-Response Antigens, Human,HLA-D,HLA-Dw,Immune Response Associated Antigens, Human,Antigens, HLA D,Antigens, HLA-Dw,Antigens, Human Ia-Like,Antigens, Human Immune-Associated,Antigens, Human Immune-Response,HLA D Antigens,HLA Dw Antigens,Human Ia-Like Antigens,Human Immune-Associated Antigens,Human Immune-Response Antigens,Ia Like Antigens, Human,Immune Associated Antigens, Human,Immune Response Antigens, Human
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001172	Arthritis, Rheumatoid	A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	Rheumatoid Arthritis
D012307	Risk Factors	An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent.	Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor