Umbilical cord mesenchymal stem cells and umbilical cord blood mononuclear cells improve neonatal rat memory after hypoxia-ischemia. 2019

Jie Zhang, and Chao Yang, and Juan Chen, and Maowen Luo, and Yi Qu, and Dezhi Mu, and Qiang Chen
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Current treatment options for hypoxic-ischemic encephalopathy (HIE) are limited. Human umbilical cord mesenchymal stem cells (UC-MSCs) and cord blood mononuclear cells (CB-MNCs) offer great potential for the treatment of many neurological diseases. The aim of the present study was to identify which cell type is more effective for the treatment of HIE. PKH26-labeled UC-MSCs and CB-MNCs were transplanted into rats with hypoxia-ischemia (HI)-induced brain damage. Apoptotic cell numbers in the brain, as labeled by TUNEL, were assessed. Myelination and gliosis were investigated using myelin basic protein and glial fibrillary acidic protein immunohistochemistry, respectively. The Morris water maze was used to assess animal learning abilities. Our data show that transplantation of UC-MSCs or CB-MNCs after HI reduced astrogliosis, prevented neuronal loss in the striatum, and markedly improved functional brain outcomes after a 28-day recovery period. Moreover, treatment with CB-MNCs increased the proportion of mature oligodendrocytes and improved myelination in cortical areas. Both UC-MSCs and CB-MNCs may result in the recovery of neurological function in HI rats. Based on our data, UC-MSCs and UCB-MNCs may be particularly effective stem cell subsets for treatment of neonatal HIE.

UI MeSH Term Description Entries
D008568 Memory Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000831 Animals, Newborn Refers to animals in the period of time just after birth. Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D014470 Umbilical Cord The flexible rope-like structure that connects a developing FETUS to the PLACENTA in mammals. The cord contains blood vessels which carry oxygen and nutrients from the mother to the fetus and waste products away from the fetus. Cord, Umbilical,Cords, Umbilical,Umbilical Cords
D045164 Mesenchymal Stem Cell Transplantation Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Stem Cell Transplantation, Mesenchymal,Transplantation, Mesenchymal Stem Cell
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D059630 Mesenchymal Stem Cells Mesenchymal stem cells, also referred to as multipotent stromal cells or mesenchymal stromal cells are multipotent, non-hematopoietic adult stem cells that are present in multiple tissues, including BONE MARROW; ADIPOSE TISSUE; and WHARTON JELLY. Mesenchymal stem cells can differentiate into mesodermal lineages, such as adipocytic, osteocytic and chondrocytic. Adipose Tissue-Derived Mesenchymal Stem Cell,Adipose Tissue-Derived Mesenchymal Stromal Cell,Adipose-Derived Mesenchymal Stem Cell,Bone Marrow Mesenchymal Stem Cell,Mesenchymal Stromal Cell,Mesenchymal Stromal Cells,Multipotent Bone Marrow Stromal Cell,Multipotent Mesenchymal Stromal Cell,Adipose Tissue-Derived Mesenchymal Stem Cells,Adipose Tissue-Derived Mesenchymal Stromal Cells,Adipose-Derived Mesenchymal Stem Cells,Adipose-Derived Mesenchymal Stromal Cells,Bone Marrow Mesenchymal Stem Cells,Bone Marrow Stromal Cell,Bone Marrow Stromal Cells,Bone Marrow Stromal Cells, Multipotent,Bone Marrow Stromal Stem Cells,Mesenchymal Progenitor Cell,Mesenchymal Progenitor Cells,Mesenchymal Stem Cell,Mesenchymal Stem Cells, Adipose-Derived,Mesenchymal Stromal Cells, Multipotent,Multipotent Bone Marrow Stromal Cells,Multipotent Mesenchymal Stromal Cells,Stem Cells, Mesenchymal,Wharton Jelly Cells,Wharton's Jelly Cells,Adipose Derived Mesenchymal Stem Cell,Adipose Derived Mesenchymal Stem Cells,Adipose Derived Mesenchymal Stromal Cells,Adipose Tissue Derived Mesenchymal Stem Cell,Adipose Tissue Derived Mesenchymal Stem Cells,Adipose Tissue Derived Mesenchymal Stromal Cell,Adipose Tissue Derived Mesenchymal Stromal Cells,Mesenchymal Stem Cells, Adipose Derived,Progenitor Cell, Mesenchymal,Progenitor Cells, Mesenchymal,Stem Cell, Mesenchymal,Stromal Cell, Mesenchymal,Stromal Cells, Mesenchymal,Wharton's Jelly Cell,Whartons Jelly Cells
D020925 Hypoxia-Ischemia, Brain A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions. Anoxia-Ischemia, Brain,Anoxia-Ischemia, Cerebral,Anoxic-Ischemic Encephalopathy,Brain Anoxia-Ischemia,Brain Hypoxia-Ischemia,Brain Ischemia-Anoxia,Brain Ischemia-Hypoxia,Cerebral Anoxia-Ischemia,Cerebral Hypoxia-Ischemia,Cerebral Ischemia-Anoxia,Cerebral Ischemia-Hypoxia,Hypoxia-Ischemia, Cerebral,Hypoxic-Ischemic Encephalopathy,Ischemia-Anoxia, Brain,Ischemia-Anoxia, Cerebral,Ischemia-Hypoxia, Brain,Ischemia-Hypoxia, Cerebral,Ischemic-Hypoxic Encephalopathy,Encephalopathy, Anoxic-Ischemic,Encephalopathy, Hypoxic-Ischemic,Anoxia Ischemia, Brain,Anoxia Ischemia, Cerebral,Anoxia-Ischemias, Brain,Anoxia-Ischemias, Cerebral,Anoxic Ischemic Encephalopathy,Anoxic-Ischemic Encephalopathies,Brain Anoxia Ischemia,Brain Anoxia-Ischemias,Brain Hypoxia Ischemia,Brain Hypoxia-Ischemias,Brain Ischemia Anoxia,Brain Ischemia Hypoxia,Brain Ischemia-Anoxias,Brain Ischemia-Hypoxias,Cerebral Anoxia Ischemia,Cerebral Anoxia-Ischemias,Cerebral Hypoxia Ischemia,Cerebral Hypoxia-Ischemias,Cerebral Ischemia Anoxia,Cerebral Ischemia Hypoxia,Cerebral Ischemia-Anoxias,Cerebral Ischemia-Hypoxias,Encephalopathies, Anoxic-Ischemic,Encephalopathies, Hypoxic-Ischemic,Encephalopathies, Ischemic-Hypoxic,Encephalopathy, Anoxic Ischemic,Encephalopathy, Hypoxic Ischemic,Encephalopathy, Ischemic-Hypoxic,Hypoxia Ischemia, Brain,Hypoxia Ischemia, Cerebral,Hypoxia-Ischemias, Brain,Hypoxia-Ischemias, Cerebral,Hypoxic Ischemic Encephalopathy,Hypoxic-Ischemic Encephalopathies,Ischemia Anoxia, Brain,Ischemia Anoxia, Cerebral,Ischemia Hypoxia, Brain,Ischemia Hypoxia, Cerebral,Ischemia-Anoxias, Brain,Ischemia-Anoxias, Cerebral,Ischemia-Hypoxias, Brain,Ischemia-Hypoxias, Cerebral,Ischemic Hypoxic Encephalopathy,Ischemic-Hypoxic Encephalopathies

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