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The present study examined the influence of age and gender on T cell populations in the lacrimal gland. Lacrimal (exorbital) glands were obtained from male and female rats at 19 days (pre-puberty), 9 weeks (adult) and 14 months (mid-life) of age and tissues were processed for T cell subset identification. In females, the density of total (W3/13+ and OX 19+), helper/inducer (W3/25+) and suppressor/cytotoxic (OX 8+) T cells underwent a significant increase in tissues from before, to after puberty. Following this rise, the density of all T cell populations decreased in glands from young adult to midlife females. This pattern of accumulation contrasted with the T cell profile presented by glands from males: T cell densities appeared unaffected from 19 days to 9 weeks of age, and then either declined (OX 19+, W3/25) or remained unchanged (W3/13+, OX 8+) in tissues of 14 month rats. An influence of gender on the distribution of T cells was also apparent if results were corrected for age-associated variations in lacrimal gland weight. Thus, the absolute number of all T cell populations rose dramatically in glands of both sexes from pre- to post-puberty. However, from 9 weeks to 14 months of age, the total content of W3/13+, OX 19+, W3/25+ and OX 8+ lymphocytes decreased 2-fold in glands of females, but did not vary in tissues of males. Of interest, the number of W3/25+ and OX 8+ cells was analagous in all age groups examined. Moreover, the combined total of W3/25+ and OX 8+ cells was greater than that of W3/13+ or OX 19+ cells at every age.(ABSTRACT TRUNCATED AT 250 WORDS)
O G Gudmundsson, and
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K Olafsdottir, and
K J Bloch, and
M R Allansmith, and
D A Sullivan
January 1988,
Archives d'anatomie et de cytologie pathologiques,
O G Gudmundsson, and
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M R Allansmith, and
D A Sullivan
January 1990,
Regional immunology,
O G Gudmundsson, and
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K Olafsdottir, and
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D A Sullivan
October 2023,
Croatian medical journal,
O G Gudmundsson, and
J Bjornsson, and
K Olafsdottir, and
K J Bloch, and
M R Allansmith, and
D A Sullivan
October 2008,
The ocular surface,
O G Gudmundsson, and
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K J Bloch, and
M R Allansmith, and
D A Sullivan
February 1988,
Acta ophthalmologica,
O G Gudmundsson, and
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D A Sullivan
January 2018,
Ophthalmic plastic and reconstructive surgery,
O G Gudmundsson, and
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K Olafsdottir, and
K J Bloch, and
M R Allansmith, and
D A Sullivan
January 1985,
The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc,
O G Gudmundsson, and
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January 1994,
Advances in experimental medicine and biology,
O G Gudmundsson, and
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January 1986,
Revista da Faculdade de Odontologia de Ribeirao Preto,
O G Gudmundsson, and
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M R Allansmith, and
D A Sullivan
February 2024,
Biofabrication,
