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[Methods] We retrospectively studied 115 con- secutive pulmonary tuberculosis patients whose sputum smear was .negative, diagnosed by positive culture and/or PCR of various samples, or positive QFT. [Results] The culture positive rate of tuberculosis by spu- tum, gastric aspirate, bronchoscopy, and computed tomogra- phy (CT)-guided needle biopsy samples was 55.7%, 45.6%, 73.2%, and 71.4%, respectively. In multivariate analysis, negative or unknown sputum PCR, negative or unknown gastric aspirate, and minimal spread of tuberculosis were risk factors for negative culture from both sputum and gas- tric aspirate. Sputum culture was positive in only one of the four patients with multi-drug resistant Mycobacterium tuberculosis. [Conclusion] Invasive diagnostic procedures such as fiber- optic bronchoscopy should be considered in patients with negative sputum PCR and minimal spread of tuberculosis.
Hironori Uruga, and
Shuhei Moriguchi, and
Yui Takahashi, and
Kazumasa Ogawa, and
Ryoko Murase, and
Shigeo Hanada, and
Atsushi Miyamoto, and
Nasa Morokawa, and
Kazuma Kishi
April 1994,
Tropical doctor,
Hironori Uruga, and
Shuhei Moriguchi, and
Yui Takahashi, and
Kazumasa Ogawa, and
Ryoko Murase, and
Shigeo Hanada, and
Atsushi Miyamoto, and
Nasa Morokawa, and
Kazuma Kishi
October 1993,
Tropical doctor,
Hironori Uruga, and
Shuhei Moriguchi, and
Yui Takahashi, and
Kazumasa Ogawa, and
Ryoko Murase, and
Shigeo Hanada, and
Atsushi Miyamoto, and
Nasa Morokawa, and
Kazuma Kishi
October 2010,
Lung India : official organ of Indian Chest Society,
Hironori Uruga, and
Shuhei Moriguchi, and
Yui Takahashi, and
Kazumasa Ogawa, and
Ryoko Murase, and
Shigeo Hanada, and
Atsushi Miyamoto, and
Nasa Morokawa, and
Kazuma Kishi
January 2012,
Archives of Iranian medicine,
Hironori Uruga, and
Shuhei Moriguchi, and
Yui Takahashi, and
Kazumasa Ogawa, and
Ryoko Murase, and
Shigeo Hanada, and
Atsushi Miyamoto, and
Nasa Morokawa, and
Kazuma Kishi
August 2001,
Chest,
Hironori Uruga, and
Shuhei Moriguchi, and
Yui Takahashi, and
Kazumasa Ogawa, and
Ryoko Murase, and
Shigeo Hanada, and
Atsushi Miyamoto, and
Nasa Morokawa, and
Kazuma Kishi
May 2008,
The European respiratory journal,
Hironori Uruga, and
Shuhei Moriguchi, and
Yui Takahashi, and
Kazumasa Ogawa, and
Ryoko Murase, and
Shigeo Hanada, and
Atsushi Miyamoto, and
Nasa Morokawa, and
Kazuma Kishi
December 1985,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
Hironori Uruga, and
Shuhei Moriguchi, and
Yui Takahashi, and
Kazumasa Ogawa, and
Ryoko Murase, and
Shigeo Hanada, and
Atsushi Miyamoto, and
Nasa Morokawa, and
Kazuma Kishi
March 1985,
Medicina clinica,
Hironori Uruga, and
Shuhei Moriguchi, and
Yui Takahashi, and
Kazumasa Ogawa, and
Ryoko Murase, and
Shigeo Hanada, and
Atsushi Miyamoto, and
Nasa Morokawa, and
Kazuma Kishi
June 2000,
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease,
Hironori Uruga, and
Shuhei Moriguchi, and
Yui Takahashi, and
Kazumasa Ogawa, and
Ryoko Murase, and
Shigeo Hanada, and
Atsushi Miyamoto, and
Nasa Morokawa, and
Kazuma Kishi
January 2005,
Respiration; international review of thoracic diseases,
