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Reversible Left Ventricular Systolic Dysfunction Secondary to Pazopanib. 2018

Kushani Gajjar, and Kathir Balakumaran, and Agnes S Kim
Internal Medicine, University of Connecticut Health Center, Farmington, USA.

Pazopanib is a tyrosine kinase inhibitor used for the treatment of advanced renal cell carcinoma and advanced soft tissue sarcoma. We describe a case report of a patient with spindle cell sarcoma who developed severe left ventricular systolic dysfunction after starting pazopanib therapy with subsequent recovery of left ventricular ejection fraction upon stopping therapy.

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