-transparent.png){kind=logo}
Mutagenicity of five benzene metabolites was examined by a fluctuation test modified by Gatehouse. The test was performed by using Salmonella typhimurium TA100 with or without a metabolic activation system. Catechol showed mutagenic activity with and without a metabolic activation system in the fluctuation test. Hydroxyhydroquinone, phenol, hydroquinone and p-benzoquinone were positive only with a metabolic activation system in this test. The Ames' plate method and preincubation method are widely used as a screening test for the mutagenic compounds. However, the fluctuation test is very useful in detecting mutagenic activity of chemicals which are negative in the Ames test though being a mutagen or carcinogen.
N Koike, and
S Haga, and
N Ubukata, and
M Sakurai, and
H Shimizu, and
A Sato
November 1987,
Sangyo igaku. Japanese journal of industrial health,
N Koike, and
S Haga, and
N Ubukata, and
M Sakurai, and
H Shimizu, and
A Sato
June 1987,
Mutation research,
N Koike, and
S Haga, and
N Ubukata, and
M Sakurai, and
H Shimizu, and
A Sato
January 1985,
Mutation research,
N Koike, and
S Haga, and
N Ubukata, and
M Sakurai, and
H Shimizu, and
A Sato
January 1982,
Mutation research,
N Koike, and
S Haga, and
N Ubukata, and
M Sakurai, and
H Shimizu, and
A Sato
June 1992,
Mutation research,
N Koike, and
S Haga, and
N Ubukata, and
M Sakurai, and
H Shimizu, and
A Sato
July 1983,
Toxicology and applied pharmacology,
N Koike, and
S Haga, and
N Ubukata, and
M Sakurai, and
H Shimizu, and
A Sato
December 1981,
Biometrics,
N Koike, and
S Haga, and
N Ubukata, and
M Sakurai, and
H Shimizu, and
A Sato
September 1988,
Journal of the National Cancer Institute,
N Koike, and
S Haga, and
N Ubukata, and
M Sakurai, and
H Shimizu, and
A Sato
September 1979,
Mutation research,
N Koike, and
S Haga, and
N Ubukata, and
M Sakurai, and
H Shimizu, and
A Sato
July 2020,
Environmental and molecular mutagenesis,
