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Design, Synthesis, and Biological Evaluation of 6-Benzoxazole Benzimidazole Derivatives with Antihypertension Activities. 2019
Zhuo Wu, and
Xiao-Lu Bao, and
Wei-Bo Zhu, and
Yan-Hui Wang, and
Nguyen Thi Phuong Anh, and
Xiao-Feng Wu, and
Yi-Jia Yan, and
Zhi-Long Chen
Department of Pharmaceutical Science and Technology, College of Chemistry and Biology, Donghua University, Shanghai 201620, China.
A series of new angiotensin II receptor 1 antagonists were prepared. They displayed nanomolar affinity to AT1 receptor and could decrease blood pressure efficiently in spontaneously hypertensive rats. Among them, compounds 1b and 2b could reduce the blood pressure with more or equal potency compared to Losartan. So, compounds 1b and 2b could be considered as potential antihypertension drug candidates.
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