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DS86760016, a Leucyl-tRNA Synthetase Inhibitor with Activity against Pseudomonas aeruginosa. 2019
Manoj Kumar, and
Madhvi Rao, and
Kedar P Purnapatre, and
Tarani Kanta Barman, and
Vattan Joshi, and
Amuliya Kashyap, and
Tridib Chaira, and
Ramesh B Bambal, and
Manisha Pandya, and
Souhaila Al Khodor, and
Dilip J Upadhyay, and
Nobuhisa Masuda
Department of Microbiology, Daiichi Sankyo India Pharma Pvt. Ltd., Gurugram, Haryana, India mkumar@sidra.org.
DS86760016 is a new leucyl-tRNA-synthetase inhibitor at the preclinical development stage. DS86760016 showed potent activity against extended-spectrum multidrug-resistant Pseudomonas aeruginosa isolated from clinical samples and in vitro biofilms. In a murine catheter-associated urinary tract infection model, DS86760016 treatment resulted in significant eradication of P. aeruginosa from the kidney, bladder, and catheter without developing drug resistance. Our data suggest that DS86760016 has the potential to act as a new drug for the treatment of Pseudomonas infections.
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