-transparent.png){kind=logo}
The lymphoblasts from 100 patients with acute lymphocytic leukaemia were investigated for the expression of receptors for sheep erythrocytes (E) and of a specific heterologous T cell antigen (T). In 17 cases, both T cell markers were expressed simultaneously on the leukaemic cells. In 13 cases only T antigens could be demonstrated on the lymphoblasts. A quantitative analysis of T antigens by immunoautoradiography revealed that the T expression of E-T+ -lymphoblasts was in general like that of E+T+-lymphocytes in the blood of normal persons, in several cases even higher. Therefore, the failure of E-rosette formation cannot be correlated to a decrease of the other T cell differentiation marker. In 7 out of 9 tested cases, a strong acid phosphatase reaction product located paranuclearly could be demonstrated. Complement-receptors were expressed in 3 of 5 cases which were also demonstrated in some cases of the E+T+-ALL group. The latter group was characterized by a T antigen expression like that of thymocytes. 4 cases of the E-T+ALL group were adults. Since the leukaemia cells of 2 cases were negative for acid phosphatase, PAS and all surface markers including cALL antigen, the T antigen can classify undifferentiated and otherwise unclassificable leukaemias. The clinical signigicance of the E-T+-ALL seems to be important since 5 out of 9 children with this type of ALL died soon after diagnosis.
E Thiel, and
H Rodt, and
D Netzel, and
D Huhn, and
G F Wündisch, and
R J Hass, and
C Bender-Götze, and
S Thierfelder
October 1983,
British journal of haematology,
E Thiel, and
H Rodt, and
D Netzel, and
D Huhn, and
G F Wündisch, and
R J Hass, and
C Bender-Götze, and
S Thierfelder
August 1986,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
E Thiel, and
H Rodt, and
D Netzel, and
D Huhn, and
G F Wündisch, and
R J Hass, and
C Bender-Götze, and
S Thierfelder
January 1979,
La Nouvelle presse medicale,
E Thiel, and
H Rodt, and
D Netzel, and
D Huhn, and
G F Wündisch, and
R J Hass, and
C Bender-Götze, and
S Thierfelder
January 1981,
British journal of haematology,
E Thiel, and
H Rodt, and
D Netzel, and
D Huhn, and
G F Wündisch, and
R J Hass, and
C Bender-Götze, and
S Thierfelder
September 1976,
La Radiologia medica,
E Thiel, and
H Rodt, and
D Netzel, and
D Huhn, and
G F Wündisch, and
R J Hass, and
C Bender-Götze, and
S Thierfelder
June 2006,
Cytopathology : official journal of the British Society for Clinical Cytology,
E Thiel, and
H Rodt, and
D Netzel, and
D Huhn, and
G F Wündisch, and
R J Hass, and
C Bender-Götze, and
S Thierfelder
January 1990,
Acta haematologica Polonica,
E Thiel, and
H Rodt, and
D Netzel, and
D Huhn, and
G F Wündisch, and
R J Hass, and
C Bender-Götze, and
S Thierfelder
January 1981,
La Pediatria medica e chirurgica : Medical and surgical pediatrics,
E Thiel, and
H Rodt, and
D Netzel, and
D Huhn, and
G F Wündisch, and
R J Hass, and
C Bender-Götze, and
S Thierfelder
July 2013,
Current opinion in hematology,
E Thiel, and
H Rodt, and
D Netzel, and
D Huhn, and
G F Wündisch, and
R J Hass, and
C Bender-Götze, and
S Thierfelder
February 2009,
The Lancet. Oncology,
