BIOMAT Database Logo BIOMAT Database Logo

[Dynamics of lipid accumulation on human aortic walls in atherosclerosis]. 1988

V R Babaev, and V N Sirotkin, and E M Tararak

The authors studied distribution of apoprotein B (apo B) and lipids containing esterified and nonesterified cholesterol (EC and NEC) in human aortic wall, using methods of indirect immunofluorescence with antibodies of apo B, and filipin and oil red 0 staining. All the examinees over 14 exhibited visually intact and atherosclerosis-affected vascular sites of accumulated apo-B-containing lipoproteins. EC, staining oil red 0, occurred only in the lipid strip and atherosclerotic plaque. Filipin-positive NEC was found in atherosclerotic plaque only. NEC disseminated extracellularly in the form of separate spherical corpuscles and homogenously. Saline pretreatment of nonfixed cryostat sections reduced the intensity of filipin homogenous staining. Mechanisms of lipids formation in vascular tissue of humans are under discussion.

UI MeSH Term Description Entries
D008077 Lipoproteins, LDL A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues. Low-Density Lipoprotein,Low-Density Lipoproteins,beta-Lipoprotein,beta-Lipoproteins,LDL(1),LDL(2),LDL-1,LDL-2,LDL1,LDL2,Low-Density Lipoprotein 1,Low-Density Lipoprotein 2,LDL Lipoproteins,Lipoprotein, Low-Density,Lipoproteins, Low-Density,Low Density Lipoprotein,Low Density Lipoprotein 1,Low Density Lipoprotein 2,Low Density Lipoproteins,beta Lipoprotein,beta Lipoproteins
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005455 Fluorescent Antibody Technique Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy. Antinuclear Antibody Test, Fluorescent,Coon's Technique,Fluorescent Antinuclear Antibody Test,Fluorescent Protein Tracing,Immunofluorescence Technique,Coon's Technic,Fluorescent Antibody Technic,Immunofluorescence,Immunofluorescence Technic,Antibody Technic, Fluorescent,Antibody Technics, Fluorescent,Antibody Technique, Fluorescent,Antibody Techniques, Fluorescent,Coon Technic,Coon Technique,Coons Technic,Coons Technique,Fluorescent Antibody Technics,Fluorescent Antibody Techniques,Fluorescent Protein Tracings,Immunofluorescence Technics,Immunofluorescence Techniques,Protein Tracing, Fluorescent,Protein Tracings, Fluorescent,Technic, Coon's,Technic, Fluorescent Antibody,Technic, Immunofluorescence,Technics, Fluorescent Antibody,Technics, Immunofluorescence,Technique, Coon's,Technique, Fluorescent Antibody,Technique, Immunofluorescence,Techniques, Fluorescent Antibody,Techniques, Immunofluorescence,Tracing, Fluorescent Protein,Tracings, Fluorescent Protein
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old

Related Publications

V R Babaev, and V N Sirotkin, and E M Tararak
FDG accumulation in aortic walls.
January 2001, Clinical nuclear medicine,
V R Babaev, and V N Sirotkin, and E M Tararak
Lipid accumulation in human aortic smooth muscle cell lysosomes.
April 1976, The American journal of pathology,
V R Babaev, and V N Sirotkin, and E M Tararak
LIPID-BINDING CAPACITY OF INTIMAL GLOBULINS IN HUMAN AORTIC ATHEROSCLEROSIS.
November 1964, Circulation,
V R Babaev, and V N Sirotkin, and E M Tararak
Study on lipids and fatty acids of the plasma and aortic walls in human and experimental atherosclerosis.
January 1968, Japanese heart journal,
V R Babaev, and V N Sirotkin, and E M Tararak
Different degrees of atherosclerosis detected by backscattered ultrasound: an in vitro study on fixed human aortic walls.
September 1983, Journal of clinical ultrasound : JCU,
V R Babaev, and V N Sirotkin, and E M Tararak
Glycosphingolipid accumulation in the aortic wall is another feature of human atherosclerosis.
October 1995, Arteriosclerosis, thrombosis, and vascular biology,
V R Babaev, and V N Sirotkin, and E M Tararak
Effects of chronic aortic coarctation on atherosclerosis and arterial lipid accumulation in the Watanabe hereditary hyperlipidemic (WHHL) rabbit.
March 1992, Atherosclerosis,
V R Babaev, and V N Sirotkin, and E M Tararak
Effect of cyclic AMP on lipid accumulation and metabolism in human atherosclerotic aortic cells.
October 1986, Atherosclerosis,
V R Babaev, and V N Sirotkin, and E M Tararak
Canine hyperlipoproteinemia and atherosclerosis. Accumulation of lipid by aortic medial cells in vivo and in vitro.
April 1977, The American journal of pathology,
V R Babaev, and V N Sirotkin, and E M Tararak
Low-density lipoprotein accumulation in aortic and coronary artery walls.
January 1969, Israel journal of medical sciences,
Copied contents to your clipboard!