This study presents the use of a modern surgical endodontic technique for the treatment of altered sensation following extrusion of endodontic filling materials. A patient presented with an altered sensation following a root canal treatment and extrusion of root filling material at the mandibular canine and lateral incisor. She was treated using a modern surgical technique that included removal of the extruded filling materials followed by root-end management and obturation. The treatment resulted in complete periapical and neurosensory healing. Modern endodontic surgery may be beneficial for patients with nerve injury due to extruded endodontic filling materials, since it enables a relatively safe removal of the irritating extruded endodontic materials, proper root-end management and preservation of the natural tooth.