Ingestible hydrogel device. 2019

Xinyue Liu, and Christoph Steiger, and Shaoting Lin, and German Alberto Parada, and Ji Liu, and Hon Fai Chan, and Hyunwoo Yuk, and Nhi V Phan, and Joy Collins, and Siddartha Tamang, and Giovanni Traverso, and Xuanhe Zhao
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Devices that interact with living organisms are typically made of metals, silicon, ceramics, and plastics. Implantation of such devices for long-term monitoring or treatment generally requires invasive procedures. Hydrogels offer new opportunities for human-machine interactions due to their superior mechanical compliance and biocompatibility. Additionally, oral administration, coupled with gastric residency, serves as a non-invasive alternative to implantation. Achieving gastric residency with hydrogels requires the hydrogels to swell very rapidly and to withstand gastric mechanical forces over time. However, high swelling ratio, high swelling speed, and long-term robustness do not coexist in existing hydrogels. Here, we introduce a hydrogel device that can be ingested as a standard-sized pill, swell rapidly into a large soft sphere, and maintain robustness under repeated mechanical loads in the stomach for up to one month. Large animal tests support the exceptional performance of the ingestible hydrogel device for long-term gastric retention and physiological monitoring.

UI MeSH Term Description Entries
D008422 Materials Testing The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility. Biocompatibility Testing,Biocompatible Materials Testing,Hemocompatibility Testing,Testing, Biocompatible Materials,Testing, Hemocompatible Materials,Hemocompatibility Testings,Hemocompatible Materials Testing,Materials Testing, Biocompatible,Materials Testing, Hemocompatible,Testing, Biocompatibility,Testing, Hemocompatibility,Testing, Materials,Testings, Biocompatibility
D008991 Monitoring, Physiologic The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine. Patient Monitoring,Monitoring, Physiological,Physiologic Monitoring,Monitoring, Patient,Physiological Monitoring
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013270 Stomach An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM. Stomachs
D055595 Mechanical Phenomena The properties and processes of materials that affect their behavior under force. Mechanical Concepts,Mechanical Processes,Mechanical Phenomenon,Mechanical Process,Concept, Mechanical,Concepts, Mechanical,Mechanical Concept,Phenomena, Mechanical,Phenomenon, Mechanical,Process, Mechanical,Processes, Mechanical
D018938 Caco-2 Cells Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells, such as ENTEROCYTES. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation. Caco 2 Cells,Caco-2 Cell,Cell, Caco-2,Cells, Caco-2
D020100 Hydrogels Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed) Hydrogel,In Situ Hydrogel,In Situ Hydrogels,Patterned Hydrogel,Patterned Hydrogels,Hydrogel, In Situ,Hydrogel, Patterned

Related Publications

Xinyue Liu, and Christoph Steiger, and Shaoting Lin, and German Alberto Parada, and Ji Liu, and Hon Fai Chan, and Hyunwoo Yuk, and Nhi V Phan, and Joy Collins, and Siddartha Tamang, and Giovanni Traverso, and Xuanhe Zhao
September 2012, Managed care (Langhorne, Pa.),
Xinyue Liu, and Christoph Steiger, and Shaoting Lin, and German Alberto Parada, and Ji Liu, and Hon Fai Chan, and Hyunwoo Yuk, and Nhi V Phan, and Joy Collins, and Siddartha Tamang, and Giovanni Traverso, and Xuanhe Zhao
February 2024, Science robotics,
Xinyue Liu, and Christoph Steiger, and Shaoting Lin, and German Alberto Parada, and Ji Liu, and Hon Fai Chan, and Hyunwoo Yuk, and Nhi V Phan, and Joy Collins, and Siddartha Tamang, and Giovanni Traverso, and Xuanhe Zhao
September 2013, Gastrointestinal endoscopy,
Xinyue Liu, and Christoph Steiger, and Shaoting Lin, and German Alberto Parada, and Ji Liu, and Hon Fai Chan, and Hyunwoo Yuk, and Nhi V Phan, and Joy Collins, and Siddartha Tamang, and Giovanni Traverso, and Xuanhe Zhao
July 2023, Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference,
Xinyue Liu, and Christoph Steiger, and Shaoting Lin, and German Alberto Parada, and Ji Liu, and Hon Fai Chan, and Hyunwoo Yuk, and Nhi V Phan, and Joy Collins, and Siddartha Tamang, and Giovanni Traverso, and Xuanhe Zhao
August 2021, Science robotics,
Xinyue Liu, and Christoph Steiger, and Shaoting Lin, and German Alberto Parada, and Ji Liu, and Hon Fai Chan, and Hyunwoo Yuk, and Nhi V Phan, and Joy Collins, and Siddartha Tamang, and Giovanni Traverso, and Xuanhe Zhao
April 2017, ACS sensors,
Xinyue Liu, and Christoph Steiger, and Shaoting Lin, and German Alberto Parada, and Ji Liu, and Hon Fai Chan, and Hyunwoo Yuk, and Nhi V Phan, and Joy Collins, and Siddartha Tamang, and Giovanni Traverso, and Xuanhe Zhao
January 2011, Food and drug law journal,
Xinyue Liu, and Christoph Steiger, and Shaoting Lin, and German Alberto Parada, and Ji Liu, and Hon Fai Chan, and Hyunwoo Yuk, and Nhi V Phan, and Joy Collins, and Siddartha Tamang, and Giovanni Traverso, and Xuanhe Zhao
January 2023, Sensors (Basel, Switzerland),
Xinyue Liu, and Christoph Steiger, and Shaoting Lin, and German Alberto Parada, and Ji Liu, and Hon Fai Chan, and Hyunwoo Yuk, and Nhi V Phan, and Joy Collins, and Siddartha Tamang, and Giovanni Traverso, and Xuanhe Zhao
September 2023, Mikrochimica acta,
Xinyue Liu, and Christoph Steiger, and Shaoting Lin, and German Alberto Parada, and Ji Liu, and Hon Fai Chan, and Hyunwoo Yuk, and Nhi V Phan, and Joy Collins, and Siddartha Tamang, and Giovanni Traverso, and Xuanhe Zhao
March 2023, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology,
Copied contents to your clipboard!