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Pharmacokinetic herb-drug interaction between ginger and crizotinib. 2020

Bruno Revol, and Elodie Gautier-Veyret, and Capucine Arrivé, and Nathalie Fouilhé Sam-Laï, and Anne McLeer-Florin, and Hélène Pluchart, and Julian Pinsolle, and Anne-Claire Toffart
Centre Régional de Pharmacovigilance, Pôle Santé Publique, CHU Grenoble Alpes, France.

The use of complementary and alternative medicine at least once during or after cancer treatment has increased over the past years from an estimated 25% in the 1970s and 1980s to more than 32% in the 1990s and to 49% after 2000. The risk of herb-drug interaction is therefore increasingly recognized as a public health problem. To the best of our knowledge, we report here the first case of interaction between ginger and anticancer drug, with serious consequences for the patient. There is an urgent need regarding complementary and alternative medicine: Both clinicians and patients should be aware of the potential interactions between herbs and prescribed drugs.

UI MeSH Term Description Entries
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077547 Crizotinib A piperidine and aminopyridine derivative that acts as an inhibitor of RECEPTOR PROTEIN-TYROSINE KINASES, including ANAPLASTIC LYMPHOMA KINASE (ALK) and HEPATOCYTE GROWTH FACTOR RECEPTOR (HGFR; c-Met). It is used in the treatment of NON-SMALL CELL LUNG CANCER. PF 02341066,PF-02341066,PF-2341066,PF02341066,Xalkori,PF 2341066,PF2341066
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy
D020939 Zingiber officinale Deciduous plant rich in volatile oil (OILS, VOLATILE). It is used as a flavoring agent and has many other uses both internally and topically. Ginger,Gingers
D041743 Herb-Drug Interactions The adverse or beneficial effect of MEDICINAL HERBS on the activity, metabolism, or toxicity of PHARMACEUTICALS. Adverse Herb-Drug Interactions,Beneficial Herb-Drug Interactions,Drug-Herb Interactions,Drug-Plant Interactions,Herbal Drug Interactions,Plant-Drug Interactions,Adverse Herb Drug Interactions,Adverse Herb-Drug Interaction,Beneficial Herb Drug Interactions,Beneficial Herb-Drug Interaction,Drug Herb Interactions,Drug Interaction, Herbal,Drug Interactions, Herbal,Drug Plant Interactions,Drug-Herb Interaction,Drug-Plant Interaction,Herb Drug Interactions,Herb-Drug Interaction,Herb-Drug Interaction, Adverse,Herb-Drug Interaction, Beneficial,Herb-Drug Interactions, Adverse,Herb-Drug Interactions, Beneficial,Herbal Drug Interaction,Interaction, Adverse Herb-Drug,Interaction, Beneficial Herb-Drug,Interaction, Drug-Herb,Interaction, Drug-Plant,Interaction, Herb-Drug,Interaction, Herbal Drug,Interaction, Plant-Drug,Interactions, Adverse Herb-Drug,Interactions, Beneficial Herb-Drug,Interactions, Drug-Herb,Interactions, Drug-Plant,Interactions, Herb-Drug,Interactions, Herbal Drug,Interactions, Plant-Drug,Plant Drug Interactions,Plant-Drug Interaction

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